Evidence map›Paper›PMID 28927552›Full record

ArticleSchizophrenia research2018

Mismatch negativity impairment is associated with deficits in identifying real-world environmental sounds in schizophrenia.

Yash B Joshi, Barbara Breitenstein, Melissa Tarasenko, Michael L Thomas, Wei-Li Chang, Joyce Sprock, Richard F Sharp, Gregory A Light

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yash B JoshiDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Barbara BreitensteinDepartment of Psychology, Humboldt University, Berlin, Germany.
Melissa TarasenkoVISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), La Jolla, CA, United States; Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Michael L ThomasDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Wei-Li ChangDepartment of Psychiatry, Columbia University, New York, NY, United States.
Joyce SprockDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Richard F SharpDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, United States.
Gregory A LightVISN-22 Mental Illness, Research, Education and Clinical Center (MIRECC), La Jolla, CA, United States; Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. Electronic address: glight@ucsd.edu.
University of California San Diego · USColumbia University · USHumboldt-Universität zu Berlin · DE

Funding

PRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRYR25MH086466 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Melissa Arbuckle, Eduardo David Leonardo · 2009 to 2026
$4.3M
Psychiatry Research Residency Training TrackR25MH101072 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NEAL R SWERDLOW · 2013 to 2026
$2.8M
Pathway(s) From Genes to Functional Deficits of Schizophrenia PatientsR01MH079777 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIGHT, GREGORY A · 2007 to 2010
$1.4M
Neuroimaging and Neurocognitive Computerized Adaptive Testing in SchizophreniaK23MH102420 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMAS, MICHAEL L · 2014 to 2018
$815k
D3 Dopamine receptor signaling in the regulation of startle gatingF30MH087109 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, WEI-LI · 2010 to 2010
$31k
NIMH NIH HHS F30 MH087109NIMH NIH HHS K23 MH102420NIMH NIH HHS L30 MH069442NIMH NIH HHS R01 MH079777NIMH NIH HHS R25 MH086466NIMH NIH HHS R25 MH101072
6 · The paper itself

Abstract

backgroundPatients with schizophrenia (SZ) have impairments in processing auditory information that have been linked to deficits in cognitive and psychosocial functioning. Dysfunction in auditory sensory processing in SZ has been indexed by mismatch negativity (MMN), an event-related potential evoked by a rare, deviant stimulus embedded within a sequence of identical standard stimuli. Although MMN deficits in SZ have been studied extensively, relatively little is known about how these deficits relate to accurately identifying real-world, ecologically-salient sounds.

methodsMMN was assessed in SZ patients (n=21) and non-psychiatric comparison subjects (NCS; n=16). Participants were also assessed in their ability to identify common environmental sounds using a subset of 80 sound clips from the International Affective Digitized Sounds 2nd Ed collection.

resultsSZ patients made significantly more errors in environmental sound identification (p<0.001, d=0.86) and showed significantly reduced MMN amplitude deficits in MMN compared to NCS (p<0.01, d=0.97). In SZ patients, MMN deficits were associated with significantly greater environmental sound identification errors (r=0.61, p<0.01).

conclusionsImpairments in early auditory information processing in schizophrenia account for significant proportions of variance in the ability to identify real-world, functionally relevant environmental sounds. This study supports the view that interventions targeting deficits in low-level auditory sensory processing may also impact more complex cognitive brain processes relevant to psychosocial disability.

Indexed as

EnvironmentSchizophrenic PsychologyAcoustic StimulationAdultArousalContingent Negative VariationElectroencephalographyEmotionsEvoked Potentials, AuditoryFemaleHumansMaleMiddle AgedPsychiatric Status Rating ScalesSchizophreniaStatistics as Topic

Identifiers

PMID28927552
PMCPMC6697420
OpenAlexW2754973084

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.