ArticleJournal of biomedical semantics2017
Towards achieving semantic interoperability of clinical study data with FHIR.
Article in Journal of biomedical semantics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electronic Health Record and Semantic Issues Using Fast Healthcare Interoperability Resources: Systematic Mapping Review.Journal of medical Internet research · 2024Pooled it
- FHIR-Former: enhancing clinical predictions through Fast Healthcare Interoperability Resources and large language models.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Clinical Trial Schedule of Activities Specification Using Fast Healthcare Interoperability Resources Definitional Resources: Mixed Methods Study.JMIR medical informatics · 2025Article
- New implementation of data standards for AI in oncology: Experience from the EuCanImage project.GigaScience · 2025Article
- HL7 FHIR-based tools and initiatives to support clinical research: a scoping review.Journal of the American Medical Informatics Association : JAMIA · 2022Article
- Fast Healthcare Interoperability Resources (FHIR) for Interoperability in Health Research: Systematic Review.JMIR medical informatics · 2022Review
- HL7 FHIR with SNOMED-CT to Achieve Semantic and Structural Interoperability in Personal Health Data: A Proof-of-Concept Study.Sensors (Basel, Switzerland) · 2022Article
- Article
- Verifying the Feasibility of Implementing Semantic Interoperability in Different Countries Based on the OpenEHR Approach: Comparative Study of Acute Coronary Syndrome Registries.JMIR medical informatics · 2021Article
- The Fast Health Interoperability Resources (FHIR) Standard: Systematic Literature Review of Implementations, Applications, Challenges and Opportunities.JMIR medical informatics · 2021Review
- Measure what we want: a taxonomy of short generic person-reported outcome and experience measures (PROMs and PREMs).BMJ open quality · 2020Article
- Article
- Experience in Developing an FHIR Medical Data Management Platform to Provide Clinical Decision Support.International journal of environmental research and public health · 2019Article
- A mobile health monitoring-and-treatment system based on integration of the SSN sensor ontology and the HL7 FHIR standard.BMC medical informatics and decision making · 2019Article
- Semantic integration of clinical laboratory tests from electronic health records for deep phenotyping and biomarker discovery.NPJ digital medicine · 2019Article
- Adapting data management education to support clinical research projects in an academic medical center.Journal of the Medical Library Association : JMLA · 2019Article
- Lessons Learned in Creating Interoperable Fast Healthcare Interoperability Resources Profiles for Large-Scale Public Health Programs.Applied clinical informatics · 2019Article
- FHIRCap: Transforming REDCap forms into FHIR resources.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2019Article
- Data sharing platforms for de-identified data from human clinical trials.Clinical trials (London, England) · 2018Article
- Patients Decision Aid System Based on FHIR Profiles.Journal of medical systems · 2018Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational clinical studies play a pivotal role in advancing medical knowledge and patient healthcare. To lessen the prohibitive costs of conducting these studies and support evidence-based medicine, results emanating from these studies need to be shared and compared to one another. Current approaches for clinical study management have limitations that prohibit the effective sharing of clinical research data.
methodsThe objective of this paper is to present a proposal for a clinical study architecture to not only facilitate the communication of clinical study data but also its context so that the data that is being communicated can be unambiguously understood at the receiving end. Our approach is two-fold. First we outline our methodology to map clinical data from Clinical Data Interchange Standards Consortium Operational Data Model (ODM) to the Fast Healthcare Interoperable Resource (FHIR) and outline the strengths and weaknesses of this approach. Next, we propose two FHIR-based models, to capture the metadata and data from the clinical study, that not only facilitate the syntactic but also semantic interoperability of clinical study data.
conclusionsThis work shows that our proposed FHIR resources provide a good fit to semantically enrich the ODM data. By exploiting the rich information model in FHIR, we can organise clinical data in a manner that preserves its organisation but captures its context. Our implementations demonstrate that FHIR can natively manage clinical data. Furthermore, by providing links at several levels, it improves the traversal and querying of the data. The intended benefits of this approach is more efficient and effective data exchange that ultimately will allow clinicians to switch their focus back to decision-making and evidence-based medicines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.