ArticleMolecules and cells2017
A Proteomics Based Approach Reveals Differential Regulation of Visceral Adipose Tissue Proteins between Metabolically Healthy and Unhealthy Obese Patients.
Article in Molecules and cells, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- A comparison between the abdominal and femoral adipose tissue proteome of overweight and obese women.Scientific reports · 2019Trial
- Differential Expressions Between Colostrum and Mature Milk in Primiparous Holstein Cows with Integrations of Lipidomic and Proteomics.Foods (Basel, Switzerland) · 2026Article
- Colchicine Suppresses Adipogenic Differentiation of Mesenchymal Stem Cells: Implications for Bone Adiposity Control.Pharmaceutics · 2026Article
- Depot-specific acetylation profiles of adipose tissues-therapeutic targets for metabolically unhealthy obesity.Diabetology & metabolic syndrome · 2025Article
- Implementation of multiomic mass spectrometry approaches for the evaluation of human health following environmental exposure.Molecular omics · 2024Review
- Clinically relevant plasma proteome for adiposity depots: evidence from systematic mendelian randomization and colocalization analyses.Cardiovascular diabetology · 2024Article
- Cardiometabolic profiles and proteomics associated with obesity phenotypes in a longitudinal cohort of young adults.Scientific reports · 2024Article
- Proteomics Investigation of the Impact of theInternational journal of molecular sciences · 2023Article
- Transcriptomic and Proteomic Analysis Reveals the Potential Role of RBMS1 in Adipogenesis and Adipocyte Metabolism.International journal of molecular sciences · 2023Article
- Article
- Multi-omics profiling: the way towards precision medicine in metabolic diseases.Journal of molecular cell biology · 2021Article
- Recent Progress in Metabolic Syndrome Research and Therapeutics.International journal of molecular sciences · 2021Review
- Obesity, metabolic health and omics: Current status and future directions.World journal of diabetes · 2021Review
- Cellular and Molecular Players in the Interplay between Adipose Tissue and Breast Cancer.International journal of molecular sciences · 2021Review
- Ingestion of lean meat elevates muscle inositol hexakisphosphate kinase 1 protein content independent of a distinct post-prandial circulating proteome in young adults with obesity.Metabolism: clinical and experimental · 2020Article
- A Proteomics-Based Approach Reveals Differential Regulation of Urine Proteins between Metabolically Healthy and Unhealthy Obese Patients.International journal of molecular sciences · 2019Article
- Metabolically Healthy Obesity and Bariatric Surgery.Obesity surgery · 2019Review
- Differences in the Plasma Proteome of Patients with Hypothyroidism before and after Thyroid Hormone Replacement: A Proteomic Analysis.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and the metabolic disorders that constitute metabolic syndrome are a primary cause of morbidity and mortality in the world. Nonetheless, the changes in the proteins and the underlying molecular pathways involved in the relevant pathogenesis are poorly understood. In this study a proteomic analysis of the visceral adipose tissue isolated from metabolically healthy and unhealthy obese patients was used to identify presence of altered pathway(s) leading to metabolic dysfunction. Samples were obtained from 18 obese patients undergoing bariatric surgery and were subdivided into two groups based on the presence or absence of comorbidities as defined by the International Diabetes Federation. Two dimensional difference in-gel electrophoresis coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was carried out. A total of 28 proteins were identified with a statistically significant difference in abundance and a 1.5-fold change (ANOVA, p ≤ 0.05) between the groups. 11 proteins showed increased abundance while 17 proteins were decreased in the metabolically unhealthy obese compared to the healthy obese. The differentially expressed proteins belonged broadly to three functional categories: (i) protein and lipid metabolism (ii) cytoskeleton and (iii) regulation of other metabolic processes. Network analysis by Ingenuity pathway analysis identified the NFκB, IRK/MAPK and PKC as the nodes with the highest connections within the connectivity map. The top network pathway identified in our protein data set related to cellular movement, hematological system development and function, and immune cell trafficking. The VAT proteome between the two groups differed substantially between the groups which could potentially be the reason for metabolic dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.