SynthesisEuropean heart journal. Quality of care & clinical outcomes2017
The relationship between preoperative frailty and outcomes following transcatheter aortic valve implantation: a systematic review and meta-analysis.
Synthesis in European heart journal. Quality of care & clinical outcomes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Association between frailty and postoperative delirium after transcatheter aortic valve replacement: a meta-analysis.Frontiers in psychiatry · 2026Pooled it
- Frailty Predicts Poor Prognosis of Patients After Percutaneous Coronary Intervention: A Meta-Analysis of Cohort Studies.Frontiers in medicine · 2021Pooled it
- Frailty as a predictor of adverse in-hospital outcomes in older patients with Takotsubo cardiomyopathy.Journal of geriatric cardiology : JGC · 2026Article
- Effect of Comprehensive Outpatient Cardiac Rehabilitation on All-Cause Mortality After Transcatheter Aortic Valve Implantation.Circulation reports · 2026Article
- The impact of frailty on postoperative complications and resource utilization in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).Nagoya journal of medical science · 2026Article
- Comprehensive assessment of sarcopenia in patients with severe aortic stenosis undergoing transcatheter valve implantation.Journal of geriatric cardiology : JGC · 2026Article
- Recovery Experiences of Older Adults and Their Caregivers After Major Elective Noncardiac Surgery.JAMA network open · 2026Article
- Multidimensional Frailty and Mortality in Transcatheter Aortic Valve Implantation Patients - Prognostic Value of the Kihon Checklist.Circulation reports · 2026Article
- Associated mortality and time spent in hospital following mitral valve intervention for mitral regurgitation according to frailty status: a nationwide Danish study.European heart journal open · 2025Article
- Predictors of Length of Stay in Hospital After Transcatheter Aortic Valve Replacement: Impact of Naples Prognostic Score.Medicina (Kaunas, Lithuania) · 2025Article
- Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women.Structural heart : the journal of the Heart Team · 2025Review
- Moving from just measuring, to acting on frailty in specialties outside geriatrics.European geriatric medicine · 2025Article
- Body composition of metabolically unhealthy normal-weight patients with aortic stenosis: a prospective cohort study.BMC cardiovascular disorders · 2024Article
- Progression of frailty and cardiovascular outcomes among Medicare beneficiaries.Journal of the American Geriatrics Society · 2024Article
- Progression of Frailty and Cardiovascular Outcomes Among Medicare Beneficiaries.medRxiv : the preprint server for health sciences · 2024Article
- Frailty as a predictor of mortality and readmission rate in secondary mitral regurgitation.Wiener klinische Wochenschrift · 2023Observational
- Impact of Baseline Anemia in Patients Undergoing Transcatheter Aortic Valve Replacement: A Prognostic Systematic Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Depression and Malnutrition for Prediction of Mortality after Transcatheter Aortic Valve Replacement: A Registry Study of a Tertiary Referral Hospital.Diagnostics (Basel, Switzerland) · 2023Article
- Article
- Frailty and the Interactions between Skeletal Muscle, Bone, and Adipose Tissue-Impact on Cardiovascular Disease and Possible Therapeutic Measures.International journal of molecular sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Aims: Transcatheter aortic valve implantation (TAVI) is an increasingly common intervention for patients with aortic stenosis deemed high risk for major cardiac surgery, but identifying those who will benefit can be challenging. Frailty reflects physiological reserve and may be a useful prognostic marker in this population. We performed a systematic review and meta-analysis of the association between frailty and outcomes after TAVI. Methods and Results: Five databases were searched between January 2000 and May 2015. From 2623 articles screened, 54 were assessed for eligibility. Ten cohort studies (n = 4592) met the inclusion criteria of reporting a measure of frailty with early (≤30 days) or late (>30 days) mortality and procedural complications following TAVI as defined by the Valve Academic Research Consortium (VARC). Frailty was associated with increased early mortality in four studies (n = 1900) (HR 2.35, 95% CI 1.78-3.09, P < 0.001) and increased late mortality in seven studies (n = 3159) (HR 1.63, 95% CI 1.34-1.97, P < 0.001). Objective frailty tools identified an even higher risk group for late mortality (HR 2.63, 95% CI 1.87-3.70, P < 0.001). Frail individuals undergoing TAVI have a mortality rate of 34 deaths per 100 patient years, compared with 19 deaths per 100 patient years in non-frail patients. There was limited reporting of VARC procedural outcomes in relation to frailty, preventing meta-analysis. Conclusion: Frailty assessment in an already vulnerable TAVI population identifies individuals at even greater risk of poor outcomes. Use of objective frailty tools may inform patient selection, but this requires further assessment in large prospective registries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.