Evidence map›Paper›PMID 28927145›Full record

ArticleOncology letters2017

BCL2/Ki-67 index predict survival in germinal center B-cell-like diffuse large B-cell lymphoma.

Yun-Long Tang, Yan Zhou, Ling-Ling Cheng, Yong-Zhong Su, Chun-Bin Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  5. Article
  6. Adult Ileoileal Intussusception Caused by Diffuse Large B-cell LymphomaJournal of community hospital internal medicine perspectives · 2023
    Article
  7. Nasal-type extranodal natural killer/T-cell lymphoma with oral ulcer as the earliest clinical manifestation.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2022
    Article
  8. Article
  9. HIV-Associated Cancer Biomarkers: A Requirement for Early Diagnosis.International journal of molecular sciences · 2021
    Review
  10. eLife · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yun-Long TangDepartment of Hematology and Oncology, The Affiliated Hospital of Southeast University, The Third People's Hospital of Yancheng, Yancheng, Jiangsu 224000, P.R. China.
Yan ZhouDepartment of Hematology and Oncology, The Affiliated Hospital of Southeast University, The Third People's Hospital of Yancheng, Yancheng, Jiangsu 224000, P.R. China.
Ling-Ling ChengDepartment of Oncology, Yancheng Hospital of Traditional Chinese Medicine, Yancheng, Jiangsu 224000, P.R. China.
Yong-Zhong SuDepartment of Hematology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515000, P.R. China.
Chun-Bin WangDepartment of Hematology and Oncology, The Affiliated Hospital of Southeast University, The Third People's Hospital of Yancheng, Yancheng, Jiangsu 224000, P.R. China.
Yancheng Third People's Hospital · CNFirst Affiliated Hospital of Shantou University Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. BCL2 apoptosis regulator (BCL2) and marker of proliferation Ki-67 (Ki-67) are established prognostic markers, which have traditionally been assessed separately in DLBCL. However, no studies have evaluated the prognostic value of the combination of BCL2 and Ki-67 index. Thus, the present study aimed to analyze the prognostic value of combination of these two markers. Immunohistochemical analysis was used to assess the expression of BCL2 and Ki-67 in 274 cases of DLBCL. The BCL2/Ki-67 index demonstrated a significant association with decreased overall and progression free survival of patients with DLBCL, particularly for the germinal center B-cell-like subtype of DLBCL. Following multivariate analysis, the BCL2/Ki-67 index retained prognostic significance. Patients with coexpression of BCL2 and Ki-67 constituted a unique group with poor survival, thus novel therapies targeting BCL2 protein and high proliferative activity may improve the outcome of these patients.

Indexed as

BCL2diffuse large B-cell lymphomaKi-67prognosis

Identifiers

PMID28927145
PMCPMC5588076
OpenAlexW2735133456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.