Evidence map›Paper›PMID 28926676›Full record

Trial reportCancer2018

Randomized controlled trial of increasing physical activity on objectively measured and self-reported cognitive functioning among breast cancer survivors: The memory & motion study.

Sheri J Hartman, Sandahl H Nelson, Emily Myers, Loki Natarajan, Dorothy D Sears, Barton W Palmer, Lauren S Weiner, Barbara A Parker, Ruth E Patterson

3 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 116 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 17 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04616300 recruitingnot on this mapstarted 2019, after this paper: background citation

Cardiorespiratory Fitness, Inflammatory Biomarkers, and Cognitive Function Patterns During Treatment for Breast Cancer: a Prospective Cohort Study

Typeobservational_patient_registrySponsorUniversity of TorontoRan2019 to 2025Enrolled50ConditionsBreast Cancer
NCT05704855 nacompletednot on this mapstarted 2023, after this paper: background citation

A Remotely-Delivered, Combined Exercise Training Program for Cognitive Function in Women Living With and Beyond Breast Cancer: A Feasibility Study

TypeinterventionalSponsorUniversity of TorontoRan2023 to 2023Enrolled21ConditionsBreast CancerArmsCombined Exercise + Behavioural Counselling, Active Control
NCT07587957 narecruitingnot on this mapstarted 2026, after this paper: background citation

Exploring the Feasibility of an Exercise and Noninvasive Brain Stimulation Intervention in Breast Cancer Survivors

TypeinterventionalSponsorFlorida Atlantic UniversityRan2026 to 2027Enrolled40ConditionsBreast CancerArmsExercise + transcranial alternating current stimulation (Ex+tACS), Control
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 17 syntheses or guidelines pooled it, 182 citations in OpenAlex.

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  5. The effect of exercise on cognitive function in breast cancer survivors: systematic review and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  13. 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5).Annals of oncology : official journal of the European Society for Medical Oncology · 2020
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  15. Psychostimulants for cancer-related cognitive impairment in adult cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Sheri J HartmanDepartment of Family Medicine and Public Health, University of California-San Diego, La Jolla, California.ORCID http://orcid.org/0000-0002-3719-0624
Sandahl H NelsonDepartment of Family Medicine and Public Health, University of California-San Diego, La Jolla, California.
Emily MyersUniversity of California-San Diego Moores Cancer Center, University of California-San Diego, La Jolla, California.
Loki NatarajanDepartment of Family Medicine and Public Health, University of California-San Diego, La Jolla, California.
Dorothy D SearsDepartment of Family Medicine and Public Health, University of California-San Diego, La Jolla, California.
Barton W PalmerDepartment of Psychiatry, University of California-San Diego, La Jolla, California.
Lauren S WeinerDepartment of Family Medicine and Public Health, University of California-San Diego, La Jolla, California.
Barbara A ParkerUniversity of California-San Diego Moores Cancer Center, University of California-San Diego, La Jolla, California.
Ruth E PattersonDepartment of Family Medicine and Public Health, University of California-San Diego, La Jolla, California.
University of California San Diego · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9M
Physical Activity and neuropsychological outcomes in a cancer populationK07CA181323 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HARTMAN, SHERI J · 2014 to 2018
$852k
NCI NIH HHS K07 CA181323
6 · The paper itself

Abstract

backgroundIncreasing physical activity can improve cognition in healthy and cognitively impaired adults; however, the benefits for cancer survivors are unknown. The current study examined a 12-week physical activity intervention, compared with a control condition, on objective and self-reported cognition among breast cancer survivors.

methodsSedentary breast cancer survivors were randomized to an exercise arm (n = 43) or a control arm (n = 44). At baseline and at 12 weeks, objective cognition was measured with the National Institutes of Health Cognitive Toolbox, and self-reported cognition using the Patient-Reported Outcomes Measurement Information System scales. Linear mixed-effects regression models tested intervention effects for changes in cognition scores.

resultsOn average, participants (n = 87) were aged 57 years (standard deviation, 10.4 years) and were 2.5 years (standard deviation, 1.3 years) post surgery. Scores on the Oral Symbol Digit subscale (a measure of processing speed) evidenced differential improvement in the exercise arm versus the control arm (b = 2.01; P < .05). The between-group differences in improvement on self-reported cognition were not statistically significant but were suggestive of potential group differences. Time since surgery moderated the correlation, and participants who were ≤2 years post surgery had a significantly greater improvement in Oral Symbol Digit score (exercise vs control (b = 4.00; P < .01), but no significant improvement was observed in patients who were >2 years postsurgery (b = -1.19; P = .40). A significant dose response was observed with greater increased physical activity associated with objective and self-reported cognition in the exercise arm.

conclusionsThe exercise intervention significantly improved processing speed, but only among those who had been diagnosed with breast cancer within the past 2 years. Slowed processing speed can have substantial implications for independent functioning, supporting the potential importance of early implementation of an exercise intervention among patients with breast cancer. Cancer 2018;124:192-202. © 2017 American Cancer Society.

Indexed as

CognitionExerciseExercise TherapyAgedBreast NeoplasmsCancer SurvivorsCognitive DysfunctionFemaleHumansMemoryMiddle AgedNeuropsychological TestsSedentary BehaviorSelf Reportbreast neoplasmsclinical trialcognitionexerciseneuropsychological tests

Identifiers

PMID28926676
PMCPMC5735009
OpenAlexW2756172936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.