Evidence map›Paper›PMID 28926618›Full record

ArticlePloS one2017

Teneurin-2 presence in rat and human odontoblasts.

K R Torres-da-Silva, G W L Tessarin, C A Dias, I Z Guiati, E Ervolino, A Gonçalves, I M Beneti, D A Lovejoy, C A Casatti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

K R Torres-da-SilvaInstitute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil.
G W L TessarinInstitute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil.
C A DiasBasic Sciences Department, School of Dentistry of Araçatuba, São Paulo State University, Araçatuba, São Paulo, Brazil.
I Z GuiatiInstitute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil.
E ErvolinoBasic Sciences Department, School of Dentistry of Araçatuba, São Paulo State University, Araçatuba, São Paulo, Brazil.
A GonçalvesBasic Sciences Department, School of Dentistry of Araçatuba, São Paulo State University, Araçatuba, São Paulo, Brazil.
I M BenetiDepartment of Surgery and Integrated Clinic, School of Dentistry of Araçatuba, São Paulo State University, Araçatuba, São Paulo, Brazil.
D A LovejoyCell and Systems Biology Department, University of Toronto, Toronto, Ontario, Canada.
C A CasattiInstitute of Biosciences of Botucatu, São Paulo State University, Botucatu, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-5650-7343
Universidade Estadual Paulista (Unesp) · BRUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teneurins are transmembrane proteins consisting of four paralogues (Ten-1-4), notably expressed in the central nervous system during development. All teneurins contain a bioactive peptide in their carboxyl terminal named teneurin C-terminal associated peptide (TCAP). The present study analyzed the detailed distribution of teneurin-2-like immunoreactive (Ten-2-LI) cells in developing and mature rat molar teeth, as well as in mature human dental pulps. Ten-2 and TCAP-2 genic expressions were also evaluated in rat and human dental pulps. Finally, Ten-2-LI cells were analyzed during the repair process after dentin-pulp complex injury in rat lower molar teeth. For this, histological sections of rat molar teeth and human dental pulps were submitted to immunohistochemical techniques, while total RNA from developing rat teeth and mature human dental pulps were submitted to conventional RT-PCR. Ten-2-LI cells were evident in the initial bell stage of rat molar teeth development, especially in ectomesenchymal cells of the dental papilla. Ten-2-LI odontoblasts showed strong immunoreactivity in rat and human mature teeth. Ten-2 and TCAP-2 genic expressions were confirmed in rat and human dental pulps. Dentin-pulp complex injury resulted in a decrease of Ten-2-LI odontoblasts after traumatic injury. Interestingly, Ten-2-LI cells were also evident in the pulp cell-rich zone in all postoperative days. In conclusion, Ten-2-LI presence in rat and human odontoblasts was demonstrated for the first time and Ten-2/TCAP-2 genic expressions were confirmed in rat and human dental pulps. Furthermore, it was revealed that Ten-2-LI rat odontoblasts can be modulated during the regenerative process.

Indexed as

AnimalsCells, CulturedDental PulpDentinFemaleHumansImmunohistochemistryMaleMicroscopy, ConfocalMolarMolar, ThirdNerve Tissue ProteinsOdontoblastsRatsRats, WistarNerve Tissue Proteins

Identifiers

PMID28926618
PMCPMC5604987
OpenAlexW2754335455

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.