Evidence map›Paper›PMID 28926443›Full record

Observational studyAnesthesiology2017

Recovery after Nulliparous Birth: A Detailed Analysis of Pain Analgesia and Recovery of Function.

Ryu Komatsu, Brendan Carvalho, Pamela D Flood

Registry-linked trialOpen access · greenAbstract readObservational Study
In one paragraph

Observational study in Anesthesiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03472521 (Prevention of Persistent Pain and Opioid Use in Mothers - POMS), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03472521 phase4completednot on this mapstarted 2018, after this paper: background citation

Prevention of Persistent Pain and Opioid Use in Mothers - POMS

TypeinterventionalSponsorStanford UniversityRan2018 to 2021Enrolled78ConditionsOpioid Use, Postpartum Disorder, Chronic Pain SyndromeArmsGabapentin, Placebo
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Care Bundles: Enhanced Recovery After Delivery.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Opioid prescribing after childbirth: overprescribing and chronic use.Current opinion in obstetrics & gynecology · 2019
    Review
  18. Article
  19. Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ryu KomatsuFrom the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.
Brendan Carvalho
Pamela D Flood
Stanford University · US

Funding

Research in Anesthesia Training Program (ReAP)T32GM089626 · NIGMS · STANFORD UNIVERSITY · PI Vivianne L Tawfik · 2010 to 2026
$5.2M
NIGMS NIH HHS T32 GM089626
6 · The paper itself

Abstract

backgroundThe majority of parturients in the United States first return for evaluation by their obstetric practitioner 6 weeks after delivery. As such, there is little granular data on the pain experience, analgesic requirements, and functional recovery during the postpartum period. This prospective observational study was performed to evaluate these factors to provide expectations for patients.

methodsA total of 213 nulliparous women were enrolled and assessed daily until they completed 3 outcomes: (1) pain resolution; (2) opioid cessation; and (3) self-assessed functional recovery from delivery. The primary endpoint, pain- and opioid-free functional recovery, was the time required to reach all three of the endpoints. Pain burden was assessed as the area under the curve created by plotting the daily numerical pain rating scale against the days required to attain pain resolution. Times to attain study endpoints after cesarean delivery and vaginal delivery were compared using survival analysis.

resultsAfter vaginal delivery, days required for pain and opioid-free functional recovery (median [interquartile range (IQR)]) were 19 [11 to 26], for opioid cessation 0 [0 to 2], termination of all analgesic (including nonsteroidal antiinflammatories and acetaminophen) 11 [5 to 17], and pain resolution 14 [7 to 24]. Achievement of these endpoints after cesarean delivery required 27 [19 to 40], 9 [5 to 12], 16 [11 to 24], and 21 [14 to 27] days, respectively.

conclusionsThere is clinically significant variability between healthy nulliparous parturients in the pain experience, opioid use, and functional recovery after childbirth following vaginal and cesarean delivery. Recovery to predelivery function is similar after vaginal and cesarean delivery, and approximately half of the variance was explained by pain burden.

Indexed as

AdultAnalgesia, ObstetricalAnalgesics, OpioidDelivery, ObstetricFemaleHumansPainParityParturitionPostpartum PeriodPregnancyProspective StudiesRecovery of FunctionAnalgesics, Opioid

Identifiers

PMID28926443
PMCPMC5657561
OpenAlexW2756679536

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.