ArticleEpidemiology (Cambridge, Mass.)2018
Exposure to Mobile Source Air Pollution in Early-life and Childhood Asthma Incidence: The Kaiser Air Pollution and Pediatric Asthma Study.
Article in Epidemiology (Cambridge, Mass.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- The odds of developing asthma and wheeze among children and adolescents exposed to particulate matter: asystematic review and meta-analysis.BMC public health · 2025Pooled it
- The first 1000 days of life: traffic-related air pollution and development of wheezing and asthma in childhood. A systematic review of birth cohort studies.Environmental health : a global access science source · 2021Pooled it
- The impact of prenatal exposure to PMEnvironmental science and pollution research international · 2020Pooled it
- Assessing the feasibility of indoor air quality monitoring in low-income housing among Black adults with uncontrolled asthma in New York City.BMC public health · 2026Article
- The Modern Environment and Childhood Asthma: The Role of Air Pollution and Heavy Metal Exposure.Current allergy and asthma reports · 2026Review
- Causal Association of Prenatal Ozone Exposure with Impaired Lung Function in Childhood.Environment & health (Washington, D.C.) · 2025Article
- Birth Cohort Studies of Long-Term Exposure to Ambient Air Pollution in Early Life and Development of Asthma in Children and Adolescents from Denmark.Research report (Health Effects Institute) · 2024Article
- The Impact of Acute Peri-operative Particulate Matter Exposure on Endoscopic Sinus Surgery Outcomes: A Preliminary Multi-site Investigation.American journal of rhinology & allergy · 2024Article
- Analysis of gasoline-related pollutant exposures and risks in California between 1996 and 2014.Journal of exposure science & environmental epidemiology · 2024Article
- Does air pollutant exposure impact disease severity or outcomes in chronic rhinosinusitis?International forum of allergy & rhinology · 2024Article
- Prenatal polycyclic aromatic hydrocarbon exposure and asthma at age 8-9 years in a multi-site longitudinal study.Environmental health : a global access science source · 2024Article
- Inflammatory response in mouse lungs to haze episodes under different backgrounds of particulate matter exposure.Scientific reports · 2023Article
- Early-Life Exposure to Ambient Air Pollution from Multiple Sources and Asthma Incidence in Children: A Nationwide Birth Cohort Study from Denmark.Environmental health perspectives · 2023Article
- The relationship between PM2.5 and the onset and exacerbation of childhood asthma: a short communication.Frontiers in pediatrics · 2023Article
- Associations of Early-Life Exposure to Submicron Particulate Matter With Childhood Asthma and Wheeze in China.JAMA network open · 2022Article
- Indoor air pollution effects on pediatric asthma are submicron aerosol particle-dependent.European journal of pediatrics · 2022Article
- Asthma in the Americas: An Update: A Joint Perspective from the Brazilian Thoracic Society, Canadian Thoracic Society, Latin American Thoracic Society, and American Thoracic Society.Annals of the American Thoracic Society · 2022Review
- Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment.Heliyon · 2021Article
- Article
- Prenatal and early life exposure to particulate matter, environmental tobacco smoke and respiratory symptoms in Mexican children.Environmental research · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundEarly-life exposure to traffic-related air pollution exacerbates childhood asthma, but it is unclear what role it plays in asthma development.
methodsThe association between exposure to primary mobile source pollutants during pregnancy and during infancy and asthma incidence by ages 2 through 6 was examined in the Kaiser Air Pollution and Pediatric Asthma Study, a racially diverse birth cohort of 24,608 children born between 2000 and 2010 and insured by Kaiser Permanente Georgia. We estimated concentrations of mobile source fine particulate matter (PM2.5, µg/m), nitrogen oxides (NOX, ppb), and carbon monoxide (CO, ppm) at the maternal and child residence using a Research LINE source dispersion model for near-surface releases. Asthma was defined using diagnoses and medication dispensings from medical records. We used binomial generalized linear regression to model the impact of exposure continuously and by quintiles on asthma risk.
resultsControlling for covariates and modeling log-transformed exposure, a 2.7-fold increase in first year of life PM2.5 was associated with an absolute 4.1% (95% confidence interval, 1.6%, 6.6%) increase in risk of asthma by age 5. Quintile analysis showed an increase in risk from the first to second quintile, but similar risk across quintiles 2-5. Risk differences increased with follow-up age. Results were similar for NOX and CO and for exposure during pregnancy and the first year of life owing to high correlation.
conclusionsResults provide limited evidence for an association of early-life mobile source air pollution with childhood asthma incidence with a steeper concentration-response relationship observed at lower levels of exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.