ArticleNano letters2017
Polypyrrole-Coated Perfluorocarbon Nanoemulsions as a Sono-Photoacoustic Contrast Agent.
Article in Nano letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Nanodroplet vaporization with pulsed-laser excitation repeatedly amplifies photoacoustic signals at low vaporization thresholds.RSC advances · 2023Article
- Polymeric materials for ultrasound imaging and therapy.Chemical science · 2023Review
- Factors Influencing the Repeated Transient Optical Droplet Vaporization Threshold and Lifetimes of Phase Change, Perfluorocarbon Nanodroplets.Nanomaterials (Basel, Switzerland) · 2023Article
- Effect of perfluorocarbon composition on activation of phase-changing ultrasound contrast agents.Medical physics · 2022Article
- Sonoporation based on repeated vaporization of gold nanodroplets.Medical physics · 2022Article
- Ultrasound-responsive polymer-based drug delivery systems.Drug delivery and translational research · 2021Review
- A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy.International journal of nanomedicine · 2021Article
- Comprehensive review on ultrasound-responsive theranostic nanomaterials: mechanisms, structures and medical applications.Beilstein journal of nanotechnology · 2021Review
- Spatially localized sono-photoacoutic activation of phase-change contrast agents.Photoacoustics · 2020Article
- Lipid Shell Retention and Selective Binding Capability Following Repeated Transient Acoustic Microdroplet Vaporization.Langmuir : the ACS journal of surfaces and colloids · 2020Article
- Investigation of light delivery geometries for photoacoustic applications using Monte Carlo simulations with multiple wavelengths, tissue types, and species characteristics.Journal of biomedical optics · 2020Article
- Leveraging the Imaging Transmit Pulse to Manipulate Phase-Change Nanodroplets for Contrast-Enhanced Ultrasound.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2019Article
- Color-coded perfluorocarbon nanodroplets for multiplexed ultrasound and Photoacoustic imaging.Nano research · 2019Article
- Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer.Chemical Society reviews · 2019Review
- Ultrasound-based formation of nano-Pickering emulsions investigated via in-situ SAXS.Journal of colloid and interface science · 2019Article
- Spontaneous Nucleation of Stable Perfluorocarbon Emulsions for Ultrasound Contrast Agents.Nano letters · 2019Article
- Colloids, nanoparticles, and materials for imaging, delivery, ablation, and theranostics by focused ultrasound (FUS).Theranostics · 2019Review
- Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors.Contrast media & molecular imaging · 2019Review
- Super-Resolution Imaging With Ultrafast Ultrasound Imaging of Optically Triggered Perfluorohexane Nanodroplets.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018Article
- A small-angle scattering environment for in situ ultrasound studies.Soft matter · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
A new contrast agent for combined photoacoustic and ultrasound imaging is presented. It has a liquid perfluorocarbon (PFC) core of about 250 nm diameter coated by a 30 nm thin polypyrrole (PPy) doped polymer shell emulsion that represents a broadband absorber covering the visible and near-infrared ranges (peak optical extinction at 1050 nm). When exposed to a sufficiently high intensity optical or acoustic pulse, the droplets vaporize to form microbubbles providing a strong increase in imaging sensitivity and specificity. The threshold for contrast agent activation can further drastically be reduced by up to 2 orders of magnitude if simultaneously exposing them with optical and acoustic pulses. The selection of PFC core liquids with low boiling points (i.e., perfluorohexane (56 °C), perfluoropentane (29 °C), and perfluorobutane (-2 °C)) facilitates activation and reduces the activation threshold of PPy-coated emulsion contrast agents to levels well within clinical safety limits (as low as 0.2 MPa at 1 mJ/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.