ArticleOrganic letters2017
Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products.
Article in Organic letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Discovery of Pyranoquinolone Diterpenoids Biosynthesized through Oxidative Indole Rearrangement and Atypical Terpene Cyclization.Journal of the American Chemical Society · 2026Article
- Complete biosynthesis of phenylspirodrimanes with unclustered genes inActa pharmaceutica Sinica. B · 2026Article
- A hybrid assembly mechanism employs nonreducing polyketide synthase-like logic for partially reduced polyketide formation.Marine life science & technology · 2026Article
- Nucleophilic addition promoted ring rearrangement-aromatization in aza-/thio-sesquiterpenoid biosynthesis.Nature communications · 2025Article
- Mapping epoxyquinoid biosynthesis: Enzyme functions across bacteria and fungi.Journal of industrial microbiology & biotechnology · 2024Review
- Identification of a chlorosalicylic acid decarboxylase (CsaD) involved in decarboxylation of 3,6-DCSA from an anaerobic dicamba-degrading sludge.Applied and environmental microbiology · 2024Article
- Fragment-Guided Genome Mining of Octacyclic Cyclophane Alkaloids from Fungi.Journal of the American Chemical Society · 2024Article
- Unusual Sesquiterpenes fromJournal of natural products · 2024Article
- Class II terpene cyclases: structures, mechanisms, and engineering.Natural product reports · 2024Review
- Global genome mining-driven discovery of an unusual biosynthetic logic for fungal polyketide-terpenoid hybrids.Chemical science · 2024Article
- The Multifaceted Gene 275 Embedded in the PKS-PTS Gene Cluster Was Involved in the Regulation of Arthrobotrisin Biosynthesis, TCA Cycle, and Septa Formation in Nematode-Trapping FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Modulating Activity Evaluation of Gut Microbiota with Versatile Toluquinol.International journal of molecular sciences · 2022Article
- Chemical Diversity and Biosynthesis of Drimane-Type Sesquiterpenes in the Fungal Kingdom.Chembiochem : a European journal of chemical biology · 2022Review
- New Trends and Future Opportunities in the Enzymatic Formation of C-C, C-N, and C-O bonds.Chembiochem : a European journal of chemical biology · 2022Review
- CRISPR-based transcriptional activation tool for silent genes in filamentous fungi.Scientific reports · 2021Article
- Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.Angewandte Chemie (International ed. in English) · 2020Article
- Regulation of Secondary Metabolism in theInternational journal of molecular sciences · 2020Review
- Marine-DerivedMarine drugs · 2020Article
- Deletion of the Histone Deacetylase HdaA in Endophytic FungusMolecules (Basel, Switzerland) · 2020Article
- Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases.Natural product reports · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Macrophorins are representative examples of isoprenoid epoxycyclohexenones containing cyclized drimane moieties. We located and characterized the biosynthetic gene cluster of macrophorin from Penicillium terrestris. MacJ encoded by this cluster was characterized to be the first example of a membrane-bound type-II terpene cyclase catalyzing the cyclization of meroterpenoids via direct protonation of the terminal olefinic bond in acyclic yanuthones. The late-stage functionalization and substrate promiscuity of MacJ make it a potential biocatalyst for the synthesis of macrophorin analogues.
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