Evidence map›Paper›PMID 28926103›Full record

ArticleJournal of cellular physiology2018

FAM20C regulates osteoblast behaviors and intracellular signaling pathways in a cell-autonomous manner.

Chao Liu, Hua Zhang, Priyam Jani, Xiaofang Wang, Yongbo Lu, Nan Li, Jing Xiao, Chunlin Qin

Abstract read
In one paragraph

Article in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Review
  3. Emerging concepts on the FGF23 regulation and activity.Molecular and cellular biochemistry · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.Clinical cancer research : an official journal of the American Association for Cancer Research · 2020
    Article
  17. Article
  18. Two NovelGenes · 2020
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Chao LiuDepartment of Oral Biology, College of Stomatology, Dalian Medical University, Dalian, Liaoning, China.ORCID 0000-0002-3584-0224
Hua ZhangDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas.
Priyam JaniDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas.
Xiaofang WangDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas.
Yongbo LuDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas.
Nan LiDepartment of Oral Biology, College of Stomatology, Dalian Medical University, Dalian, Liaoning, China.
Jing XiaoDepartment of Oral Biology, College of Stomatology, Dalian Medical University, Dalian, Liaoning, China.
Chunlin QinDepartment of Biomedical Sciences, Texas A&M University College of Dentistry, Dallas, Texas.
Dalian Medical University · CN

Funding

The Roles of FAM20C (DMP4) in Odontogenesis and OsteogenesisR01DE022549 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI QIN, CHUNLIN · 2013 to 2017
$1.8M
NIDCR NIH HHS R01 DE022549
6 · The paper itself

Abstract

Recent studies indicate that Family with sequence similarity 20 member C (FAM20C) catalyzes the phosphorylation of secreted proteins, and participates in a variety of biological processes, including cell proliferation, migration, mineralization, and phosphate homeostasis. To explore the local influences of FAM20C on osteoblast, Fam20c-deficient osteoblasts were generated by treating the immortalized Fam20c

Indexed as

Calcification, PhysiologicCalcium-Binding ProteinsCasein Kinase ICell DifferentiationCell ProliferationExtracellular Matrix ProteinsFibroblast Growth Factor-23HomeostasisHumansOsteoblastsOsteocalcinOsteogenesisSignal TransductionCalcium-Binding ProteinsCasein Kinase IExtracellular Matrix ProteinsFAM20C protein, humanFGF23 protein, humanFibroblast Growth Factor-23OsteocalcinFAM20Cmineralizationosteoblastphosphorylationsecretory proteins

Identifiers

PMID28926103
PMCPMC5741497
OpenAlexW2755128267

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.