ArticleTranslational psychiatry2017
Polygenic loading for major depression is associated with specific medical comorbidity.
Article in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Exploring polygenic contributors to subgroups of comorbid conditions in autism spectrum disorder.Scientific reports · 2022Pooled it
- Testing bidirectional associations of major depressive disorder with medical conditions: two-sample Mendelian randomization study.Npj mental health research · 2026Article
- Topic modeling identifies novel genetic loci associated with multimorbidities in UK Biobank.Cell genomics · 2023Article
- Depression Genetics as a Window Into Physical and Mental Health.Biological psychiatry · 2022Article
- Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-wide Association Study of 46,782 Individuals.Biological psychiatry · 2022Article
- Characterizing DSM-5 and ICD-11 personality disorder features in psychiatric inpatients at scale using electronic health records.Psychological medicine · 2020Article
- Assessment of a Prediction Model for Antidepressant Treatment Stability Using Supervised Topic Models.JAMA network open · 2020Article
- Using phenome-wide association to investigate the function of a schizophrenia risk locus at SLC39A8.Translational psychiatry · 2019Article
- Article
- Shared Genetics of Psychiatric Disorders.F1000Research · 2019Review
- Association networks in a matched case-control design - Co-occurrence patterns of preexisting chronic medical conditions in patients with major depression versus their matched controls.Journal of biomedical informatics · 2018Article
- Genome-wide association identifies a novel locus for delirium risk.Neurobiology of aging · 2018Article
- High Throughput Phenotyping for Dimensional Psychopathology in Electronic Health Records.Biological psychiatry · 2018Article
- Distribution of agitation and related symptoms among hospitalized patients using a scalable natural language processing method.General hospital psychiatryArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Major depressive disorder frequently co-occurs with medical disorders, raising the possibility of shared genetic liability. Recent identification of 15 novel genetic loci associated with depression allows direct investigation of this question. In cohorts of individuals participating in biobanks at two academic medical centers, we calculated polygenic loading for risk loci reported to be associated with depression. We then examined the association between such loading and 50 groups of clinical diagnoses, or topics, drawn from these patients' electronic health records, determined using a novel application of latent Dirichilet allocation. Three topics showed experiment-wide association with the depression liability score; these included diagnostic groups representing greater prevalence of mood and anxiety disorders, greater prevalence of cardiac ischemia, and a decreased prevalence of heart failure. The latter two associations persisted even among individuals with no mood disorder diagnosis. This application of a novel method for grouping related diagnoses in biobanks indicate shared genetic risk for depression and cardiac disease, with a pattern suggesting greater ischemic risk and diminished heart failure risk.
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