Evidence map›Paper›PMID 28925405›Full record

Trial reportInternational journal of obesity (2005)2018

Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study.

N M Byrne, A Sainsbury, N A King, A P Hills, R E Wood

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06079658 (The Effects of Continuous vs. Intermittent Caloric Restriction on Fat Loss), which is not on this map. Cited by 61 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 10 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06079658 nacompletednot on this mapstarted 2022, after this paper: background citation

The Effects of Continuous vs. Intermittent Caloric Restriction on Fat Loss: A Randomized Controlled Trial

TypeinterventionalSponsorCoastal Carolina UniversityRan2022 to 2023Enrolled40ConditionsObesityArmsContinuous Caloric Restriction versus Intermittent Caloric Restriction on Fat Loss
3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 10 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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  13. Effect of Time-Restricted Eating on Metabolic Adaptation in Adults With Severe Obesity During Early Phase of Weight Loss.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

N M ByrneSchool of Health Sciences, Faculty of Health, University of Tasmania, Launceston, Tasmania, Australia.
A SainsburyThe Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School, Charles Perkins Centre, The University of Sydney, Camperdown New South Wales, Australia.
N A KingQueensland University of Technology, School of Exercise and Nutrition Sciences and Institute of Health and Biomedical Innovation, Brisbane, Queensland, Australia.
A P HillsSchool of Health Sciences, Faculty of Health, University of Tasmania, Launceston, Tasmania, Australia.
R E WoodSchool of Health Sciences, Faculty of Health, University of Tasmania, Launceston, Tasmania, Australia.
Queensland University of Technology · AUUniversity of Tasmania · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThe MATADOR (Minimising Adaptive Thermogenesis And Deactivating Obesity Rebound) study examined whether intermittent energy restriction (ER) improved weight loss efficiency compared with continuous ER and, if so, whether intermittent ER attenuated compensatory responses associated with ER. SUBJECTS/

methodsFifty-one men with obesity were randomised to 16 weeks of either: (1) continuous (CON), or (2) intermittent (INT) ER completed as 8 × 2-week blocks of ER alternating with 7 × 2-week blocks of energy balance (30 weeks total). Forty-seven participants completed a 4-week baseline phase and commenced the intervention (CON: N=23, 39.4±6.8 years, 111.1±9.1 kg, 34.3±3.0 kg

resultsFor the N=19 CON and N=17 INT who completed the intervention per protocol, weight loss was greater for INT (14.1±5.6 vs 9.1±2.9 kg; P<0.001). INT had greater FM loss (12.3±4.8 vs 8.0±4.2 kg; P<0.01), but FFM loss was similar (INT: 1.8±1.6 vs CON: 1.2±2.5 kg; P=0.4). Mean weight change during the 7 × 2-week INT energy balance blocks was minimal (0.0±0.3 kg). While reduction in absolute REE did not differ between groups (INT: -502±481 vs CON: -624±557 kJ d

conclusionsGreater weight and fat loss was achieved with intermittent ER. Interrupting ER with energy balance 'rest periods' may reduce compensatory metabolic responses and, in turn, improve weight loss efficiency.

Indexed as

Caloric RestrictionAdultBasal MetabolismBody CompositionEnergy IntakeEnergy MetabolismFemaleHumansMaleMiddle AgedObesityRestThermogenesisTreatment OutcomeWeight Loss

Identifiers

PMID28925405
PMCPMC5803575
OpenAlexW2746923267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.