Evidence map›Paper›PMID 28925356›Full record

ArticleeLife2017

The

Sarah N Deffit, Brian A Yee, Aidan C Manning, Suba Rajendren, Pranathi Vadlamani, Emily C Wheeler, Alain Domissy, Michael C Washburn, Gene W Yeo, Heather A Hundley

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Probing RNA-protein interactions in the early mouse embryo.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. ADARs mediate distinct RNA editing activity and gene regulation in thebioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Review
  10. ncRNA Editing: Functional Characterization and Computational Resources.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. ADR-2 regulates fertility and oocyte fate inbioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sarah N DeffitMedical Sciences Program, Indiana University, Bloomington, Indiana.
Brian A YeeDepartment of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, United States.
Aidan C ManningMedical Sciences Program, Indiana University, Bloomington, Indiana.
Suba RajendrenDepartment of Biology, Indiana University, Bloomington, Indiana.
Pranathi VadlamaniMedical Sciences Program, Indiana University, Bloomington, Indiana.
Emily C WheelerDepartment of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, United States.
Alain DomissyDepartment of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, United States.
Michael C WashburnDepartment of Biology, Indiana University, Bloomington, Indiana.
Gene W YeoDepartment of Cellular and Molecular Medicine, Stem Cell Program and Institute for Genomic Medicine, University of California at San Diego, San Diego, United States.
Heather A HundleyMedical Sciences Program, Indiana University, Bloomington, Indiana.ORCID http://orcid.org/0000-0002-9106-9016
Indiana University Bloomington · USUniversity of California San Diego · USAgency for Science, Technology and Research · SG

Funding

Functional RNA elements in the human genomeR01HG004659 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Kevin Daniel Corbett, Eugene Wei-Ming Yeo · 2008 to 2026
$12.4M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Defining the messenger RNP code in the brainR01NS075449 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YEO, EUGENE WEI-MING · 2012 to 2016
$3.0M
Regulation of A-to-I editing in NeuronsF32GM119257 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI DEFFIT, SARAH N · 2017 to 2017
$42k
NHGRI NIH HHS R01 HG004659NIGMS NIH HHS F32 GM119257NIGMS NIH HHS T32 GM008666NIH HHS P40 OD010440NINDS NIH HHS R01 NS075449
6 · The paper itself

Abstract

ADAR proteins alter gene expression both by catalyzing adenosine (A) to inosine (I) RNA editing and binding to regulatory elements in target RNAs. Loss of ADARs affects neuronal function in all animals studied to date.

Indexed as

ChemotaxisGene Expression RegulationAdenosineAdenosine DeaminaseAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression ProfilingInosineRNA, MessengerAdenosineAdenosine DeaminaseAdr-2 protein, C elegansCaenorhabditis elegans ProteinsInosineRNA, MessengerADARC. eleganschromosomesevolutionary biologygene expressiongenesgenomicsinosinepost-transcriptional gene regulationRNA biologyRNA editing

Identifiers

PMID28925356
PMCPMC5644944
OpenAlexW2753983118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.