ArticleeLife2017
BMPs direct sensory interneuron identity in the developing spinal cord using signal-specific not morphogenic activities.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Who cites it
30 citing papers in PubMed.
- Graded BMP signals modulate yellow and red color in fishes, impacting adult pigment patterns and conspecific shoaling behavior.Current biology : CB · 2026Article
- A controllable human spinal cord model with full dorsoventral patterning.Nature communications · 2026Article
- Graded BMP signals modulate yellow and red color in fishes impacting adult pigment pattern and behavior.bioRxiv : the preprint server for biology · 2025Article
- Receptor dimerization enables ligand discrimination through tunable response heterogeneity.PLoS computational biology · 2025Article
- Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks.PLoS biology · 2025Article
- Neural plate pre-patterning enables specification of intermediate neural progenitors in the spinal cord.bioRxiv : the preprint server for biology · 2025Article
- Netrin1 patterns the dorsal spinal cord through modulation of Bmp signaling.Cell reports · 2024Article
- Generation of self-renewing neuromesodermal progenitors with neuronal and skeletal muscle bipotential from human embryonic stem cells.Cell reports methods · 2024Article
- Investigating the basis of lineage decisions and developmental trajectories in the dorsal spinal cord through pseudotime analyses.Development (Cambridge, England) · 2024Article
- BMPRIINeural regeneration research · 2024Article
- Small-Molecule Probes as Pharmacological Tools for the Bone Morphogenetic Protein Signaling Pathway.ACS pharmacology & translational science · 2023Review
- BMP-9 Improves the Osteogenic Differentiation Ability over BMP-2 through p53 Signaling In Vitro in Human Periosteum-Derived Cells.International journal of molecular sciences · 2023Article
- Accelerated differentiation of human induced pluripotent stem cells into regionally specific dorsal and ventral spinal neural progenitor cells for application in spinal cord therapeutics.Frontiers in neuroscience · 2023Article
- Spatial transcriptomics in glioblastoma: is knowing the right zip code the key to the next therapeutic breakthrough?Frontiers in oncology · 2023Review
- Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns.Science advances · 2022Article
- In vitro atlas of dorsal spinal interneurons reveals Wnt signaling as a critical regulator of progenitor expansion.Cell reports · 2022Article
- Ligand-receptor promiscuity enables cellular addressing.Cell systems · 2022Article
- The context-dependent, combinatorial logic of BMP signaling.Cell systems · 2022Article
- Article
- Getting in touch with your senses: Mechanisms specifying sensory interneurons in the dorsal spinal cord.WIREs mechanisms of disease · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The Bone Morphogenetic Protein (BMP) family reiteratively signals to direct disparate cellular fates throughout embryogenesis. In the developing dorsal spinal cord, multiple BMPs are required to specify sensory interneurons (INs). Previous studies suggested that the BMPs act as concentration-dependent morphogens to direct IN identity, analogous to the manner in which sonic hedgehog patterns the ventral spinal cord. However, it remains unresolved how multiple BMPs would cooperate to establish a unified morphogen gradient. Our studies support an alternative model: BMPs have signal-specific activities directing particular IN fates. Using chicken and mouse models, we show that the identity, not concentration, of the BMP ligand directs distinct dorsal identities. Individual BMPs promote progenitor patterning or neuronal differentiation by their activation of different type I BMP receptors and distinct modulations of the cell cycle. Together, this study shows that a 'mix and match' code of BMP signaling results in distinct classes of sensory INs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.