Evidence map›Paper›PMID 28925323›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

Recanalization, reperfusion, and recirculation in stroke.

John H Zhang, Andre Obenaus, David S Liebeskind, Jiping Tang, Richard Hartman, William J Pearce

Abstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Argatroban Increased the Basal Vein Drainage and Improved Outcomes in Acute Paraventricular Ischemic Stroke Patients.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Trial
  2. The value of venous outflow assessment based on multiphase CTA in predicting the prognosis of endovascular therapy for acute ischemic stroke patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

John H Zhang1 Center for Neuroscience Research, 4608 Loma Linda University School of Medicine, Loma Linda, CA, USA.ORCID http://orcid.org/0000-0002-4319-4285
Andre Obenaus1 Center for Neuroscience Research, 4608 Loma Linda University School of Medicine, Loma Linda, CA, USA.
David S Liebeskind2 Neurovascular Imaging Research Core and Department of Neurology, UCLA, CA, USA.
Jiping Tang1 Center for Neuroscience Research, 4608 Loma Linda University School of Medicine, Loma Linda, CA, USA.
Richard Hartman1 Center for Neuroscience Research, 4608 Loma Linda University School of Medicine, Loma Linda, CA, USA.
William J Pearce1 Center for Neuroscience Research, 4608 Loma Linda University School of Medicine, Loma Linda, CA, USA.

Funding

Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3M
Vascular Biology Core FacilityP01NS082184 · NINDS · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2014 to 2018
$6.1M
Cerebrovascular Myosin Light Chain Phosphorylation in Fetus, Newborn, and AdultR01NS076945 · NINDS · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2011 to 2015
$1.5M
NICHD NIH HHS P01 HD083132NINDS NIH HHS P01 NS082184NINDS NIH HHS R01 NS076945
6 · The paper itself

Abstract

Recirculation, from arterial inflow routes through venous outflow pathways, was conceptualized in stroke research 50 years ago. As new technologies were developed, blocked arteries could be reopened, capillaries could be reperfused, and the use of recanalization and reperfusion grew to dominate therapeutic strategies. These approaches overwhelmingly focused on restoration of arterial and capillary inflow, but not on veins even though venous disorders may initiate or exacerbate brain injury. In this commentary, we advance the term "recirculation" after "recanalization" and "reperfusion" as a primary concept of stroke pathophysiology that targets the restoration of both the arterial and venous cerebral circulations.

Indexed as

Cerebrovascular CirculationAnimalsArteriesBrainHumansReperfusionStrokeVeinsRecanalizationrecirculationreperfusionstroke pathophysiologystroke treatment

Identifiers

PMID28925323
PMCPMC5718333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.