ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018
Hemodynamics and oxygen extraction in chronic large artery steno-occlusive disease: Clinical applications for predicting stroke risk.
Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- A Data-Driven Normalization Framework for Subject-Specific Cerebrovascular Reactivity Assessment in Cerebrovascular Disease.Journal of magnetic resonance imaging : JMRI · 2026Article
- Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults.GeroScience · 2026Article
- Acute normobaric hypoxia as a reversible probe of oxygen-limitation contributions to cognitive aging.Aging brain · 2026Review
- Cerebral oxygen extraction and blood flow in community-based older adults: associations with white matter hyperintensity and neurocognitive function.Brain communications · 2026Article
- Benefits and challenges of multi-delay arterial spin labeling in clinical practice: measuring perfusion and cerebrovascular reactivity in intracranial steno-occlusive disease.Insights into imaging · 2025Article
- Correlation between P2-PCA Volume Flow Rate and BOLD Cerebrovascular Reactivity in Patients with Symptomatic Carotid Artery Occlusion.AJNR. American journal of neuroradiology · 2025Article
- Oxygen extraction fraction in small vessel disease: relationship to disease burden and progression.Brain : a journal of neurology · 2025Article
- Dynamic PET imaging in patients with unilateral carotid occlusion shows lateralized cerebral hypoperfusion, but no amyloid binding.Journal of Alzheimer's disease : JAD · 2025Article
- Estimation of hypoperfused tissue volume in large vessel occlusions: pseudo-continuous arterial spin labeling versus dynamic susceptibility contrast perfusion-weighted imaging.Quantitative imaging in medicine and surgery · 2025Article
- BOLD Cerebrovascular Reactivity and NOVA Quantitative MR Angiography in Adult Patients with Moyamoya Vasculopathy Undergoing Cerebral Bypass Surgery.Brain sciences · 2024Article
- Significance of atherosclerotic plaque location in recanalizing non-acute long-segment occlusion of the internal carotid artery.Scientific reports · 2024Article
- Safety and effectiveness assessment of endovascular recanalization for non-acute middle cerebral artery occlusion.CNS neuroscience & therapeutics · 2024Article
- Article
- Hemodynamic Failure Staging With Blood Oxygenation Level-Dependent Cerebrovascular Reactivity and Acetazolamide-Challenged (Journal of the American Heart Association · 2023Article
- Asymmetry of Lacunae between Brain Hemispheres Is Associated with Atherosclerotic Occlusions of Middle Cerebral Artery.Brain sciences · 2023Article
- Profile of precipitating factors and its implication in 160 Indian patients with Moyamoya angiopathy.Journal of neurology · 2023Observational
- Impaired oxygen extraction and adaptation of intracellular energy metabolism in cerebral small vessel disease.Cerebral circulation - cognition and behavior · 2023Article
- Personalised simulation of hemodynamics in cerebrovascular disease: lessons learned from a study of diagnostic accuracy.Frontiers in neurology · 2023Article
- Oxygen extraction efficiency and white matter lesion burden in older adults exhibiting radiological evidence of capillary shunting.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
- Cerebral oxygen extraction fraction MRI: Techniques and applications.Magnetic resonance in medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depending on the adequacy of collateral sources of blood flow, arterial stenosis or occlusion may lead to reduced perfusion pressure and ultimately reduced blood flow in the distal territory supplied by that vessel. There are two well-defined compensatory mechanisms to reduced pressure or flow - autoregulatory vasodilation and increased oxygen extraction fraction. Other changes, such as metabolic downregulation, are likely. The positive identification of autoregulatory vasodilation and increased oxygen extraction fraction in humans is an established risk factor for future ischemic stroke in some disease states such as atherosclerotic carotid stenosis and occlusion. The mechanisms by which ischemic stroke may occur are not clear, and may include an increased vulnerability to embolic events. The use of hemodynamic assessment to identify patients with occlusive vasculopathy at an increased risk for stroke is very appealing for several different patient populations, such as those with symptomatic intracranial atherosclerotic disease, moyamoya phenomenon, complete internal carotid artery occlusion, and asymptomatic cervical carotid artery stenosis. While there is very good data for stroke risk prediction in some of these groups, no intervention based on these tools has been proven effective yet. In this manuscript, we will review these topics above and identify areas for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.