Evidence map›Paper›PMID 28925060›Full record

ReviewMolecular nutrition & food research2018

Current (Food) Allergenic Risk Assessment: Is It Fit for Novel Foods? Status Quo and Identification of Gaps.

Gabriel Mazzucchelli, Thomas Holzhauser, Tanja Cirkovic Velickovic, Araceli Diaz-Perales, Elena Molina, Paola Roncada, Pedro Rodrigues, Kitty Verhoeckx, Karin Hoffmann-Sommergruber

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular nutrition & food research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Novel foods: allergenicity assessment of insect proteins.EFSA journal. European Food Safety Authority · 2022
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Rare food allergens.Allergologie select · 2021
    Review
  12. Article
  13. Review
  14. New Perspectives in Food Allergy.International journal of molecular sciences · 2020
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 9 institutions in 9 countries.

Gabriel MazzucchelliLaboratory of Mass Spectrometry - MolSys, Department of Chemistry, University of Liege, Liege, Belgium.
Thomas HolzhauserDivision of Allergology, Paul-Ehrlich-Institut, Langen, Germany.
Tanja Cirkovic VelickovicCenter of Excellence for Molecular Food Sciences, University of Belgrade - Faculty of Chemistry, Belgrade, Serbia.
Araceli Diaz-PeralesCenter for Plant Biotechnology and Genomic (UPM-INIA), Madrid, Spain.
Elena MolinaCIAL (CSIC-UAM), Madrid, Spain.
Paola RoncadaIstituto Sperimentale Italiano Lazzaro Spallanzani, Milano, Italy.
Pedro RodriguesCCMAR, Center of Marine Science, University of Algarve, Faro, Portugal.
Kitty VerhoeckxRAPID, TNO, The Hague, The Netherlands.
Karin Hoffmann-SommergruberDepartment of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.
Centre for Plant Biotechnology and Genomics · ESIstituto Sperimentale Italiano Lazzaro Spallanzani · ITMedical University of Vienna · ATNetherlands Organisation for Applied Scientific Research · NLPaul Ehrlich Institut · DEUniversidad Autónoma de Madrid · ESUniversity of Algarve · PTUniversity of Belgrade – Faculty of ChemistryUniversity of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Food allergies are recognized as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well-known foods and foods containing genetically modified ingredients is installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consumption. In this context safety issues such as a potential increased allergenic risk need to be assessed before marketing novel food sources. Therefore, the established allergenic risk assessment for genetically modified organisms needs to be re-evaluated for its applicability for risk assessment of novel food proteins. Two different scenarios of allergic sensitization have to be assessed. The first scenario is the presence of already known allergenic structures in novel foods. For this, a comparative assessment can be performed and the range of cross-reactivity can be explored, while in the second scenario allergic reactions are observed toward so far novel allergenic structures and no reference material is available. This review summarizes the current analytical methods for allergenic risk assessment, highlighting the strengths and limitations of each method and discussing the gaps in this assessment that need to be addressed in the near future.

Indexed as

Risk AssessmentAllergensFood AnalysisFood HypersensitivityHumansOrganisms, Genetically ModifiedProtein Structure, SecondaryProtein Structure, TertiaryProteomicsRecombinant ProteinsSpectroscopy, Fourier Transform InfraredAllergensRecombinant Proteinsallergenic risk assessmentanalytical methodscross-reactivityfood allergynovel food

Identifiers

PMID28925060
PMCPMC5814866
OpenAlexW2755653632

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.