ArticleBritish journal of pharmacology2017
A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (K
Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 37 citations in OpenAlex.
- Mutation-Induced Pocket Deactivation: How Ser353/Pro245 Alters KArchiv der Pharmazie · 2026Article
- Structural mechanisms for inhibition and activation of human small-conductance CaNature communications · 2026Article
- Mechanism of SK2 channel gating and its modulation by the bee toxin apamin and small molecules.eLife · 2025Article
- NaInternational journal of cardiology. Heart & vasculature · 2025Article
- Cryo-EM structures of the small-conductance CaNature communications · 2025Article
- Identification of novel inhibitors of the transcriptional coactivator MRTF-A for HCC therapy.Molecular therapy. Oncology · 2024Article
- Challenges in the Therapeutic Targeting of KCa Channels: From Basic Physiology to Clinical Applications.International journal of molecular sciences · 2024Review
- From Atrial Small-conductance Calcium-activated Potassium Channels to New Antiarrhythmics.European cardiology · 2024Review
- KBiomedicines · 2023Review
- Gating kinetics and pharmacological properties of small-conductance CaBiophysical journal · 2023Article
- Subtype-Selective Positive Modulation of KACS chemical biology · 2022Article
- Channelopathy-causing mutations in the SCell calcium · 2022Article
- Effective termination of atrial fibrillation by SK channel inhibition is associated with a sudden organization of fibrillatory conduction.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021Article
- Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent CaActa physiologica (Oxford, England) · 2021Article
- Inhibition of Small-Conductance Calcium-Activated Potassium Current (Frontiers in physiology · 2021Article
- LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis.Molecular biology reports · 2020Article
- Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels.Annual review of pharmacology and toxicology · 2020Review
- Inhibition of KFrontiers in pharmacology · 2020Article
- Mechanisms of Action of the KCa2-Negative Modulator AP30663, a Novel Compound in Development for Treatment of Atrial Fibrillation in Man.Frontiers in pharmacology · 2020Article
- The KFrontiers in pharmacology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeSmall conductance calcium-activated potassium (K EXPERIMENTAL APPROACH: Using site-directed mutagenesis, binding determinants for AP14145 inhibition were explored. AP14145 selectivity and mechanism of action were investigated by patch-clamp recordings of heterologously expressed K KEY
resultsAP14145 was found to be an equipotent negative allosteric modulator of K CONCLUSIONS AND IMPLICATIONS: AP14145 is a negative allosteric modulator of K
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.