ArticleMovement disorders clinical practice
Effects of subthalamic nucleus deep brain stimulation on objective sleep outcomes in Parkinson's disease.
Article in Movement disorders clinical practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Randomized, Controlled Trial of Exercise on Objective and Subjective Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2020Trial
- Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms.Neuroscience bulletin · 2026Review
- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Article
- Burden and disutility of sleep disturbance and early morning OFF symptoms in people with advancing Parkinson's disease: a vignette-based approach using the EQ-5D-5L.Journal of patient-reported outcomes · 2026Article
- Effects of Different STN-DBS Programming Strategies on Non-Motor Symptoms in Parkinson's Disease: A Retrospective Controlled Study.Journal of multidisciplinary healthcare · 2026Article
- The effect of pallidal stimulation on sleep outcomes and related brain connectometries in Parkinson's disease.NPJ Parkinson's disease · 2024Article
- Fundamentals of deep brain stimulation for Parkinson's disease in clinical practice: part 1.Arquivos de neuro-psiquiatria · 2024Review
- The effects of deep brain stimulation on sleep: a systematic review and meta-analysis.Sleep advances : a journal of the Sleep Research Society · 2024Review
- Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson's disease.Frontiers in human neuroscience · 2023Article
- Quantitative Sleep Electroencephalogram in Parkinson's Disease: A Case-Control Study.Journal of Parkinson's disease · 2023Article
- Parkinsonian daytime sleep-wake classification using deep brain stimulation lead recordings.Neurobiology of disease · 2023Article
- Beyond the brain-computer interface: Decoding brain activity as a tool to understand neuronal mechanisms subtending cognition and behavior.Frontiers in neuroscience · 2022Review
- Management of Sleep Disturbances in Parkinson's Disease.Journal of Parkinson's disease · 2022Review
- Slow Wave Sleep and EEG Delta Spectral Power are Associated with Cognitive Function in Parkinson's Disease.Journal of Parkinson's disease · 2021Article
- The Impact of Deep Brain Stimulation on Sleep in Parkinson's Disease: An update.Journal of Parkinson's disease · 2020Review
- Automatic Sleep Stage Classification Based on Subthalamic Local Field Potentials.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2019Article
- Deep Brain Stimulation and Sleep-Wake Disturbances in Parkinson Disease: A Review.Frontiers in neurology · 2018Review
- Pedestrian safety in patients with Parkinson's disease: A case-control study.Movement disorders : official journal of the Movement Disorder Society · 2017Article
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7 authors.
Funding
Abstract
backgroundSleep dysfunction is a common and disabling non-motor symptom in Parkinson's disease. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor symptoms and subjective sleep in PD, but alternative stimulation parameters to optimize sleep have not been explored. We hypothesized that low frequency STN DBS would improve objective sleep more than conventional settings.
methodsTwenty PD subjects with STN DBS (18 unilateral, 2 bilateral) underwent 3 non-consecutive nights of polysomnography: DBS off; DBS high frequency (≥130 Hz); and DBS low frequency (60 Hz). Motor symptom tolerability was assessed 30 minutes after resumption of baseline settings the morning following polysomnography. The primary outcome was change in sleep efficiency between high and low frequency nights measured with repeated measures ANOVA.
resultsThere was no difference in sleep efficiency between nights at high frequency (82.1% (72.6-90.1)) (median (IQR)), low frequency (81.2% (56.2-88.8)), or DBS off (82.8% (75.7-87.4)), p=0.241. Additionally, there was no difference in sleep stage percent, arousals, limb movements, subjective sleep quality, or objective vigilance measures. These outcomes did not change after adjusting for age, sex, disease duration, or side of surgery. No residual adverse motor effects were noted.
conclusionsAlthough well tolerated, low frequency STN DBS did not improve objective sleep in PD. Remarkably, objective measures of sleep were not worse with DBS off. These observations point to the potential for adaptive stimulation approaches, through which DBS settings could be optimized during sleep to meet individual needs. Additionally, these changes could preserve battery life without compromising patient outcomes.
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