ArticleBalkan journal of medical genetics : BJMG2017
Analysis of the Mitochondrial 4977 Bp Deletion in Patients with Hepatocellular Carcinoma.
Article in Balkan journal of medical genetics : BJMG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Mitochondrial DNA mutations and intercellular mitochondrial transfer in cancer: mechanisms, biological effects, and clinical potential.Biomarker research · 2026Review
- Targeting Regulatory Noncoding RNAs in Human Cancer: The State of the Art in Clinical Trials.Pharmaceutics · 2025Review
- Mitochondrial DNA common deletion in cancer: Emerging evidence and methodological challenges.Computational and structural biotechnology journal · 2025Review
- Review
- Maternally transmitted diabetes mellitus may be associated with mitochondrial ND5 T12338C and tRNAIrish journal of medical science · 2022Article
- A study on the cellular and cytotoxic effects of S and Se heterocycles on the myeloid leukemia cell line PLB-985.Phosphorus, sulfur, and silicon and the related elements · 2022Article
- Mitochondrial dysfunction, UPRCell & bioscience · 2021Review
- The Uprising of Mitochondrial DNA Biomarker in Cancer.Disease markers · 2021Review
- Prevalence of mitochondrial DNA common deletion in patients with gliomas and meningiomas: A first report from a Malaysian study group.Journal of the Chinese Medical Association : JCMA · 2020Article
- mtDNA deletions responsible for unsuccessful pregnancy after in- vitro fertilization.International journal of reproductive biomedicine · 2020Article
- Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma.Scientific reports · 2020Article
- Role of the mitochondrial stress response in human cancer progression.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Molecular Changes Induced by Oxidative Stress that Impair Human Sperm Motility.Antioxidants (Basel, Switzerland) · 2020Review
- ROS as a novel indicator to predict anticancer drug efficacy.BMC cancer · 2019Article
- Review
- A comprehensive overview of mitochondrial DNA 4977-bp deletion in cancer studies.Oncology reviews · 2019Article
- Prenatal Lipopolysaccharide Exposure Promotes Dyslipidemia in the Male Offspring Rats.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the mitochondrial (mt) genome that result in mt dysfunction, have long been proposed to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). Among these, the common mtDNA 4977 bp deletion is one of the most frequent mutations observed in various cancers. To understand the relationship between the mtDNA 4977 bp deletion and HCC, we performed mutational screening for the presence of this deletion in 105 HCC patients and 69 unrelated healthy subjects. After nested-polymerase chain reaction (nested-PCR) amplification, we found that there were 10 patients carrying the mtDNA 4977 bp deletion, and this deletion was absent in control subjects. Moreover, HCC patients carrying this deletion showed a marked increase in reactive oxygen species (ROS) level and mtDNA copy number when compared with the healthy controls. Taken together, our data indicated that the mtDNA 4977 bp deletion may play important role in the carcinogenesis of HCC, possibly
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