ReviewCureus2017
The Interplay of Genetics and Environmental Factors in the Development of Obesity.
Review in Cureus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations ofNutrients · 2019Pooled it
- Trial
- Bifidobacterium adolescentis attenuates brown adipose tissue whitening and improves metabolic markers in high-fat diet-induced obese rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Article
- Maternal Inflammatory Biomarkers at 28 Weeks of Pregnancy and Childhood Adiposity at Age 7 and 13 Years in the Seychelles Child Development Study.Maternal and child health journal · 2026Article
- Structured Exercise Modulates Gut Microbiota Composition and Protects Against Diet-Induced Dysbiosis in a Rat Model.Nutrients · 2026Article
- Longitudinal sex-specific impacts of high-fat diet on dopaminergic dysregulation and behavior from periadolescence to late adulthood.Nutritional neuroscience · 2025Article
- Article
- The collaborative cross mouse for studying the effect of host genetic background on memory impairments due to obesity and diabetes.Animal models and experimental medicine · 2025Article
- Transcriptional and epigenetic changes after dietary and surgical weight loss interventions in an animal model of obesity.International journal of obesity (2005) · 2024Article
- Validity and reliability of Turkish version of the Adult Eating Behaviour Questionnaire for adult participants.Public health nutrition · 2023Article
- Association between PTPN1 polymorphisms and obesity-related phenotypes in European adolescents: influence of physical activity.Pediatric research · 2023Article
- Could Naringenin Participate as a Regulator of Obesity and Satiety?Molecules (Basel, Switzerland) · 2023Review
- The effect ofBiology of sport · 2022Article
- Family Factors Affecting the Transition of Children from Normal Weight to Obesity in Mexico.Childhood obesity (Print) · 2022Article
- Risk Factors for Obesity in Five-Year-Old Children: Based on Korean National Health Insurance Service (NHIS) Data.Children (Basel, Switzerland) · 2022Article
- Genetic polymorphisms and plasma concentrations of leptin (rs7799039) and adiponectin (rs17300539) are associated with obesity in children and adolescents.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2022Article
- Genetics, epigenetics and transgenerational transmission of obesity in children.Frontiers in endocrinology · 2022Review
- What Is the Role of Gut Microbiota in Obesity Prevalence? A Few Words about Gut Microbiota and Its Association with Obesity and Related Diseases.Microorganisms · 2021Review
- Prevalence of Metabolic Syndrome and its Components in Kanifing Municipality, The Gambia.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2021Article
- Lifestyle Genetics-Based Reports in the Treatment of Obesity.Archives of Razi Institute · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a major health issue in the developed nations, and it has been increasingly clear that both genetics and environment play an important role in determining if an individual will be obese or not. We reviewed the latest researches which were carried out to identify the obesity susceptible genes and to identify the metabolic pathways having a central role in energy balance. Obesity is a heritable disorder, and some of the many obesity susceptible genes are fat mass and obesity (FTO), leptin, and Melanocortin-4 receptor (MC4R). Glucose metabolism is the central pathway for fatty acid synthesis, de novo generating the major substrate acetyl-CoA. Further knowledge of these genes and their complex interaction with the environment will help devise individual, family and community-based preventive lifestyle interventions as well as nutritional and medical therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.