ArticleCancer cell international2017
SNP rs3202538 in 3'UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population.
Article in Cancer cell international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Polymorphism rs1057147 located in mesothelin gene predicts lymph node metastasis in patients with gastric cancer.Applied microbiology and biotechnology · 2023Article
- The Importance of SNPs at miRNA Binding Sites as Biomarkers of Gastric and Colorectal Cancers: A Systematic Review.Journal of personalized medicine · 2022Review
- miR-323a regulates ERBB4 and is involved in depression.Molecular psychiatry · 2021Article
- Genetic deletion of miR-204 improves glycemic control despite obesity in db/db mice.Biochemical and biophysical research communications · 2020Article
- LINC01315 Impairs microRNA-211-Dependent DLG3 Downregulation to Inhibit the Development of Oral Squamous Cell Carcinoma.Frontiers in oncology · 2020Article
- FKBP1A rs6041749 polymorphism is associated with allograft function in renal transplant patients.European journal of clinical pharmacology · 2019Article
- ACancer cell international · 2019Article
- Relationship between serum levels of miR-204 and clinical features of patients with lumbar disc herniation - an analysis based on 1,589 cases.Experimental and therapeutic medicine · 2018Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsErbB3 is an oncogene which has proliferation and metastasis promotion effects by several signaling pathways. However, the individual expression difference regulated by miRNA was almost still unknown. We focused on the miRNAs associated SNPs in the 3'-UTR of ErbB3 to investigate the further relationship of the SNPs with miRNAs among Chinese gastric cancer (GC) patients.
methodsWe performed case-control study including 851 GC patients and 799 cancer-free controls. Genotyping, real-time PCR assay, cell transfection, the dual luciferase reporter assay, western-blot, cell proliferation and trans-well based cell invasion assay were used to investigate the effects of the SNP on ErbB3 expression. Moreover, a 5-years-overall survival and relapse free survival were investigated between different genotypes.
resultsWe found that patients suffering from
conclusionIn conclusion, our findings have shown that the SNP rs3202538 (G/T) in ErbB3 3'-UTR acted as promotion factors in the GC development through disrupting the regulatory role of miR-204 and miR-211 in ErbB3 expression.
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