ArticleInternational journal of biological sciences2017
Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes.
Article in International journal of biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Osthole attenuates cartilage degradation and chondrocyte pyroptosis in knee osteoarthritis and is associated with activation of the PI3K/Akt pathway.Molecular biology reports · 2026Article
- Heterotopic Ossification: Molecular Drivers, Subtype-Specific Mechanisms, and Translational Therapeutic Advances.Biomolecules · 2026Review
- Article
- Targeting type H vessels with bioactive metabolites from traditional Chinese botanical drugs: a therapeutic strategy for skeletal disorders.Frontiers in pharmacology · 2025Review
- Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade.Molecular medicine (Cambridge, Mass.) · 2024Article
- Role of hedgehog signaling in the pathogenesis and therapy of heterotopic ossification.Frontiers in cell and developmental biology · 2024Review
- Synthetic Calcium-Phosphate Materials for Bone Grafting.Polymers · 2023Review
- Review on the protective activity of osthole against the pathogenesis of osteoporosis.Frontiers in pharmacology · 2023Review
- Kefir alters craniomandibular bone development in rats fed excess dose of high fructose corn syrup.Journal of bone and mineral metabolism · 2022Article
- Endocrine role of bone in the regulation of energy metabolism.Bone research · 2021Review
- Effects of Osthole on Progesterone Secretion in Chicken Preovulatory Follicles Granulosa Cells.Animals : an open access journal from MDPI · 2020Article
- TGF-β/Smad2 signalling regulates enchondral bone formation of Gli1Cell proliferation · 2020Article
- Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol-induced osteonecrosis of the femoral head.Journal of cellular and molecular medicine · 2020Article
- Amygdalin Promotes Fracture Healing through TGF-Stem cells international · 2020Article
- MicroRNA-186 improves fracture healing through activating the bone morphogenetic protein signalling pathway by inhibiting SMAD6 in a mouse model of femoral fracture: An animal study.Bone & joint research · 2019Article
- Osthole inhibits the progression of human gallbladder cancer cells through JAK/STAT3 signal pathway both in vitro and in vivo.Anti-cancer drugs · 2019Article
- Osthole: A Coumarin Derivative Assuage Thiram-Induced Tibial Dyschondroplasia by RegulatingAntioxidants (Basel, Switzerland) · 2019Article
- Different effects of Wnt/β-catenin activation and parathyroid hormone on diaphyseal and metaphyseal in the early phase of femur bone healing of mice.Clinical and experimental pharmacology & physiology · 2019Article
- Article
- BMP-dependent, injury-induced stem cell niche as a mechanism of heterotopic ossification.Stem cell research & therapy · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fracture procedure in 10-week-old C57BL/6 mice which were treated with or without Osthole. Our previous studies demonstrated that chondrocyte BMP signaling is required for bone fracture healing, in this study we also performed tibial fracture procedure in Cre-negative and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.