Evidence map›Paper›PMID 28924233›Full record

ArticleScientific reports2017

Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.

Brian York, Feng Li, Fumin Lin, Kathrina L Marcelo, Jianqiang Mao, Adam Dean, Naomi Gonzales, David Gooden, Suman Maity, Cristian Coarfa and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
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  11. Molecular Mechanisms Underlying CaInternational journal of molecular sciences · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Brian YorkDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. york@bcm.edu.
Feng LiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Fumin LinDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Kathrina L MarceloDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Jianqiang MaoDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Adam DeanDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Naomi GonzalesDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
David GoodenDepartment of Chemistry, Duke University, Durham, NC, USA.
Suman MaityDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Cristian CoarfaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Nagireddy PutluriDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Anthony R MeansDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Baylor College of Medicine · USChildren's Cancer Center · USDuke University · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
STRUCTURE/FUNCTION OF GENETIC ENGINEERED CALMODULINSR01GM033976 · NIGMS · DUKE UNIVERSITY · PI MEANS, ANTHONY R · 1985 to 2015
$5.4M
NCI NIH HHS P30 CA125123NIGMS NIH HHS R01 GM033976
6 · The paper itself

Abstract

Binding of calcium to its intracellular receptor calmodulin (CaM) activates a family of Ca

Indexed as

BenzimidazolesNaphthalimidesNon-alcoholic Fatty Liver DiseaseAnimalsCalcium-Calmodulin-Dependent Protein Kinase KinaseDisease Models, AnimalHumansMaleMiceMicrosomes, LiverBenzimidazolesCalcium-Calmodulin-Dependent Protein Kinase KinaseCamkk2 protein, mouseNaphthalimidesSTO 609

Identifiers

PMID28924233
PMCPMC5603587
OpenAlexW2755047481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.