Evidence map›Paper›PMID 28924229›Full record

Trial reportScientific reports2017

Variations in oral microbiota associated with oral cancer.

Hongsen Zhao, Min Chu, Zhengwei Huang, Xi Yang, Shujun Ran, Bin Hu, Chenping Zhang, Jingping Liang

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 260 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
260citing papers in PubMed, 4 pooled it
19.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

260 citing papers in PubMed, 4 syntheses or guidelines pooled it, 427 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies.International journal of environmental research and public health · 2021
    Pooled it
  5. Trial
  6. Review
  7. Article
  8. IntratumoralJournal for immunotherapy of cancer · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Analysis ofF1000Research · 2026
    Article
  17. Article
  18. Review
  19. Periodontitis and Systemic Health: An Interconnected Relationship.Advances in experimental medicine and biology · 2026
    Review
  20. Review

200 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hongsen ZhaoNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Endodontics and Operative Dentistry, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Min ChuNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Endodontics and Operative Dentistry, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Zhengwei HuangNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Endodontics and Operative Dentistry, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Xi YangNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Prosthodontics, Shanghai, 200011, China.
Shujun RanNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Endodontics and Operative Dentistry, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.
Bin HuNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Prosthodontics, Shanghai, 200011, China. hub1093@2m9h.net.
Chenping ZhangNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai, 200011, China. zhang.chenping@hotmail.com.
Jingping LiangNinth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Department of Endodontics and Operative Dentistry, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China. liangjpdentist@126.com.
Shanghai Jiao Tong University · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individual bacteria and shifts in microbiome composition are associated with human disease, including cancer. To unravel the connections underlying oral bacterial dysbiosis and oral squamous cell carcinoma (OSCC), cancer lesion samples and anatomically matched normal samples were obtained from the same patients. We then profiled the bacteria within OSCC lesion surface samples at the species level using next-generation sequencing to comprehensively investigate bacterial community composition and functional genes in these samples. Significantly greater bacterial diversity was observed in the cancer samples than in the normal samples. Compared with previous studies, we identified many more taxa demonstrating remarkably different distributions between the groups. In particular, a group of periodontitis-correlated taxa, including Fusobacterium, Dialister, Peptostreptococcus, Filifactor, Peptococcus, Catonella and Parvimonas, was significantly enriched in OSCC samples. Additionally, several operational taxonomic units (OTUs) associated with Fusobacterium were highly involved in OSCC and demonstrated good diagnostic power. Our study revealed drastic changes in surface bacterial communities of OSCC. The findings enrich knowledge of the association between oral bacterial communities and oral cancer.

Indexed as

BacteriaMicrobiotaCarcinoma, Squamous CellFemaleHumansMaleMiddle AgedMouth Neoplasms

Identifiers

PMID28924229
PMCPMC5603520
OpenAlexW2755818420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.