Evidence map›Paper›PMID 28924128›Full record

ArticleInternal medicine (Tokyo, Japan)2017

IgG4-related Hypophysitis with Subtle Hypopituitarism in an Elderly Diabetic Patient: Is Treatment or Observation Preferable?

Motoki Kawasaki, Motoyoshi Tsujino, Fuminori Sato, Maya Sakurada, Kenji Nishida, Takayasu Kise, Yuko Hijioka, Mitsugu Ishizawa, Kazuaki Enatsu, Yoshihiro Ogawa

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Motoki KawasakiDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Tama Medical Center, Japan.
Motoyoshi TsujinoDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Tama Medical Center, Japan.
Fuminori SatoDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Tama Medical Center, Japan.
Maya SakuradaDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Tama Medical Center, Japan.
Kenji NishidaDepartment of Endocrinology and Metabolism, Tokyo Metropolitan Tama Medical Center, Japan.
Takayasu KiseDepartment of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Japan.
Yuko HijiokaDepartment of Gastroenterology, Tokyo Metropolitan Tama Medical Center, Japan.
Mitsugu IshizawaDepartment of Pathology, Tokyo Metropolitan Tama Medical Center, Japan.
Kazuaki EnatsuDepartment of Pathology, Tokyo Metropolitan Tama Medical Center, Japan.
Yoshihiro OgawaDepartment of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan.
Tokyo Metropolitan Tama Medical Center · JPTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 70-year-old man with diabetes mellitus presented with an enlarged pituitary stalk in 2014. IgG4-related parotitis and submandibular sialoadenitis were diagnosed in 2012. He denied any symptoms related to a pituitary mass. His visual field was intact, and his hypopituitarism was subtle. The serum IgG4 level was elevated. A lip biopsy revealed strong fibrosis and hyper-infiltration of IgG4-positive plasma cells. Based on these findings, IgG4-related hypophysitis was diagnosed. The patient was carefully followed without specific intervention. His clinical condition showed no change until December 2016, suggesting a stable, natural course. Care should be taken when considering glucocorticoid therapy, especially for elderly diabetic patients, given possible side effects.

Indexed as

AgedAutoimmune HypophysitisBiopsyHumansHypopituitarismImmunoglobulin GMalePituitary GlandPlasma CellsImmunoglobulin Gdiabetes mellitusglucocorticoidhypophysitishypopituitarismIgG4natural course

Identifiers

PMID28924128
PMCPMC5675934
OpenAlexW2754335447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.