ArticleThe Journal of biological chemistry2017
Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells.
Erratum issuedOpen access · hybridAbstract readComparative Study
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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23citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
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- Chronic Morphine Treatment Leads to a Global DNA Hypomethylation via Active and Passive Demethylation Mechanisms in mESCs.International journal of molecular sciences · 2025Article
- New perspectives on DNA methylation modifications in ocular diseases.International journal of ophthalmology · 2025Review
- The Information Theory of Aging.Nature aging · 2023Review
- Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway.BMC medicine · 2023Article
- Epigenetics Approaches toward Precision Medicine for Idiopathic Pulmonary Fibrosis: Focus on DNA Methylation.Biomedicines · 2023Review
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- The dynamics of chromatin states mediated by epigenetic modifications during somatic cell reprogramming.Frontiers in cell and developmental biology · 2023Review
- Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins.Aging and disease · 2022Article
- DNA Methylation in Regulatory T Cell Differentiation and Function: Challenges and Opportunities.Biomolecules · 2022Review
- Droplet Microarray Based Screening Identifies Proteins for Maintaining Pluripotency of hiPSCs.Advanced healthcare materials · 2022Article
- Epigenetic control of ataxin-1 in multiple sclerosis.Annals of clinical and translational neurology · 2022Article
- Regulatory T Cells-Related Genes Are under DNA Methylation Influence.International journal of molecular sciences · 2021Review
- Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation.Cell regeneration (London, England) · 2021Review
- Codependency of Metabolism and Epigenetics Drives Cancer Progression: A Review.Acta histochemica et cytochemica · 2020Review
- Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming.Frontiers in cell and developmental biology · 2020Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 3 institutions in 1 country.
Songwei HeFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Hao SunFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Lilong LinFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Yixin ZhangFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Jinlong ChenFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Lining LiangFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Yuan LiFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Mengdan ZhangFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Xiao YangFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Xiaoshan WangFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Fuhui WangFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Feiyan ZhuFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Jiekai ChenFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Duanqing PeiFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436.
Hui ZhengFrom the CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences between Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China and Guangzhou Medical University, Guangzhou, Guangdong 511436, zheng_hui@gibh.ac.cn.
Guangzhou Medical University · CNUniversity of Chinese Academy of Sciences · CNGuangzhou Institutes of Biomedicine and Health · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
A high proliferation rate has been observed to facilitate somatic cell reprogramming, but the pathways that connect proliferation and reprogramming have not been reported. DNA methyltransferase 1 (DNMT1) methylates hemimethylated CpG sites produced during S phase and maintains stable inheritance of DNA methylation. Impairing this process results in passive DNA demethylation. In this study, we show that the cell proliferation rate positively correlated with the expression of
Indexed as
Cellular ReprogrammingDNA DemethylationGene Expression RegulationPromoter Regions, GeneticAnimalsBiomarkersCell Line, TransformedCell ProliferationCells, CulturedCpG IslandsDNA (Cytosine-5-)-Methyltransferase 1Embryo, MammalianEpithelial-Mesenchymal TransitionG1 PhaseG2 PhaseGreen Fluorescent ProteinsBiomarkersDNA (Cytosine-5-)-Methyltransferase 1Dnmt1 protein, mouseGreen Fluorescent ProteinsRecombinant Fusion ProteinsRecombinant Proteinscell proliferationDNA methylationDNA methyltransferasep53reprogramming
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