Evidence map›Paper›PMID 28923985›Full record

Trial reportArchives of disease in childhood. Fetal and neonatal edition2018

Randomised trial of cord clamping and initial stabilisation at very preterm birth.

Lelia Duley, Jon Dorling, Angela Pushpa-Rajah, Sam J Oddie, Charles William Yoxall, Bernard Schoonakker, Lucy Bradshaw, Eleanor J Mitchell, Joe Anthony Fawke, Cord Pilot Trial Collaborative Group

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 66 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04413097 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Delayed Cord Clamping With Oxygen In Extremely Low Gestation Infants

TypeinterventionalSponsorSharp HealthCareRan2021 to 2026Enrolled140ConditionsIVH- Intraventricular Hemorrhage, Extreme Prematurity, Hypoxia Neonatal, HyperoxiaArmsDelayed Cord Clamping with Low Oxygen concentration, Delayed Cord Clamping with High Oxygen concentration
NCT06408376 narecruitingnot on this mapstarted 2022, after this paper: background citation

Physiological Umbilical Cord Clamping in Patients With Congenital Diaphragmatic Hernia. Clinical Trial

TypeinterventionalSponsorHospital JP GarrahanRan2022 to 2026Enrolled80ConditionsUmbilical Cord Clamping, Congenital Diaphragmatic Hernia, Delayed Umbilical Cord SeparationArmsPhysiological cord clamping
3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  18. Randomised trial of cord clamping at very preterm birth: outcomes at 2 years.Archives of disease in childhood. Fetal and neonatal edition · 2020
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lelia DuleyNottingham Clinical Trials Unit, Queen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0001-6721-5178
Jon DorlingEarly Life Research Group, Queen's Medical Centre, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-1691-3221
Angela Pushpa-RajahDepartment of Dermatology, Guy's Hospital, London, UK.
Sam J OddieCentre for Reviews and Dissemination, Hull York Medical School, University of York, Heslington, York, UK.
Charles William YoxallNeonatal Unit, Liverpool Women's Hospital, Liverpool, UK.
Bernard SchoonakkerNeonatal Intensive Care Unit, City Hospital, Nottingham, UK.
Lucy BradshawNottingham Clinical Trials Unit, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Eleanor J MitchellNottingham Clinical Trials Unit, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Joe Anthony FawkeNeonatal Unit, Leicester Royal Infirmary, Leicester, UK.
Cord Pilot Trial Collaborative Group

Funding

Department of Health RP-PG-0609-10107
6 · The paper itself

Abstract

objectivesFor very preterm births, to compare alternative policies for umbilical cord clamping and immediate neonatal care.

designParallel group randomised (1:1) trial, using sealed opaque numbered envelopes.

settingEight UK tertiary maternity units.

participants261 women expected to have a live birth before 32 weeks, and their 276 babies.

interventionsCord clamping after at least 2 min and immediate neonatal care with cord intact, or clamping within 20 s and immediate neonatal care after clamping.

main outcome measuresIntraventricular haemorrhage (IVH), death before discharge.

results132 women (137 babies) were allocated clamping ≥2 min and neonatal care cord intact, and 129 (139) clamping ≤20 s and neonatal care after clamping; six mother-infant dyads were excluded (2, 4) as birth was after 35

conclusionsThis is promising evidence that clamping after at least 2 min and immediate neonatal care with cord intact at very preterm birth may improve outcome; a large trial is urgently needed.

trial registrationISRCTN 21456601.

Indexed as

Cerebral Intraventricular HemorrhageInfant DeathInfant, Premature, DiseasesPremature BirthAdultConstrictionFemaleGestational AgeHumansInfantInfant, NewbornInfant, Very Low Birth WeightIntensive Care, NeonatalMalePregnancyTime-to-Treatmentcord clampingintraventricular haemorrhageneonatal care with umbilical cord intactpreterm birthrandomised trial

Identifiers

PMID28923985
PMCPMC5750367

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.