Evidence map›Paper›PMID 28923977›Full record

ArticleThe Journal of cell biology2017

Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair.

Mitsutoshi Nakamura, Jeffrey M Verboon, Susan M Parkhurst

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. eLife · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Patterning of the cell cortex by Rho GTPases.Nature reviews. Molecular cell biology · 2024
    Review
  7. Review
  8. Two Septin Complexes Mediate Actin Dynamics During Cell Wound Repair.bioRxiv : the preprint server for biology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mitsutoshi NakamuraBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.ORCID 0000-0001-7879-3176
Jeffrey M VerboonBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Susan M ParkhurstBasic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA susanp@fredhutch.org.ORCID 0000-0001-5806-9930
Fred Hutch Cancer Center · US

Funding

Molecular and Cellular Mechanisms of Wound RepairR01GM111635 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PARKHURST, SUSAN M · 2015 to 2025
$4.8M
NIGMS NIH HHS R01 GM111635
6 · The paper itself

Abstract

Like tissues, single cells are subjected to continual stresses and damage. As such, cells have a robust wound repair mechanism comprised of dynamic membrane resealing and cortical cytoskeletal remodeling. One group of proteins, the Rho family of small guanosine triphosphatases (GTPases), is critical for this actin and myosin cytoskeletal response in which they form distinct dynamic spatial and temporal patterns/arrays surrounding the wound. A key mechanistic question, then, is how these GTPase arrays are formed. Here, we show that in the

Indexed as

ActinsAnimalsAnnexinsCell Cycle ProteinsCytoskeletonDrosophila melanogasterDrosophila ProteinsEmbryo, NonmammalianGene Expression Regulation, DevelopmentalGTPase-Activating ProteinsGTP-Binding ProteinsGuanine Nucleotide Exchange FactorsHumansModels, Biologicalrac GTP-Binding Proteinsrho GTP-Binding ProteinsActinsAnnexinsCdc42 protein, DrosophilaCell Cycle ProteinsDrosophila ProteinsGTPase-Activating ProteinsGTP-Binding ProteinsGuanine Nucleotide Exchange FactorsPbl protein, DrosophilaRac1 protein, Drosophilarac GTP-Binding ProteinsRho1 protein, DrosophilarhoGEF3 protein, Drosophilarho GTP-Binding ProteinsRNA, Small Interferingsav protein, Drosophilatum protein, Drosophila

Identifiers

PMID28923977
PMCPMC5716286
OpenAlexW2754465175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.