Evidence map›Paper›PMID 28923950›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Single-molecule visualization of

Jacob S Lewis, Lisanne M Spenkelink, Grant D Schauer, Flynn R Hill, Roxanna E Georgescu, Michael E O'Donnell, Antoine M van Oijen

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mitotic kinase regulation of DNA replication forks.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Revised mechanism of hydroxyurea-induced cell cycle arrest and an improved alternative.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The TIMELESS effort for timely DNA replication and protection.Cellular and molecular life sciences : CMLS · 2023
    Review
  17. Article
  18. Rad53 arrests leading and lagging strand DNA synthesis via distinct mechanisms in response to DNA replication stress.BioEssays : news and reviews in molecular, cellular and developmental biology · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Jacob S LewisCentre for Medical & Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Lisanne M SpenkelinkCentre for Medical & Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Grant D SchauerHoward Hughes Medical Institute, Rockefeller University, New York, NY 10065.
Flynn R HillCentre for Medical & Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia.
Roxanna E GeorgescuHoward Hughes Medical Institute, Rockefeller University, New York, NY 10065.
Michael E O'DonnellHoward Hughes Medical Institute, Rockefeller University, New York, NY 10065 odonnel@rockefeller.edu vanoijen@uow.edu.au.
Antoine M van OijenCentre for Medical & Molecular Bioscience, University of Wollongong, Wollongong, NSW 2522, Australia; odonnel@rockefeller.edu vanoijen@uow.edu.au.
Rockefeller University · USUniversity of Wollongong · AUIllawarra Health and Medical Research Institute · AUUniversity of Groningen · NL

Funding

Mechanisms of Cell Regulation and TransformationT32CA009673 · NCI · ROCKEFELLER UNIVERSITY · PI KAPOOR, TARUN M. · 1991 to 2018
$7.0M
Biochemical Mechanism and Structure of the Eukaryotic Replication ForkR01GM115809 · NIGMS · ROCKEFELLER UNIVERSITY · PI O'DONNELL, MICHAEL E · 2015 to 2022
$2.6M
BYPASS MECHANISMS IN EUKARYOTIC REPLICATIONR00GM126143 · NIGMS · COLORADO STATE UNIVERSITY · PI SCHAUER, GRANT · 2019 to 2021
$747k
Bypass Mechanisms in Eukaryotic ReplicationK99GM126143 · NIGMS · ROCKEFELLER UNIVERSITY · PI SCHAUER, GRANT · 2018 to 2018
$90k
Howard Hughes Medical InstituteNCI NIH HHS T32 CA009673NIGMS NIH HHS K99 GM126143NIGMS NIH HHS R00 GM126143NIGMS NIH HHS R01 GM115809
6 · The paper itself

Abstract

The replisome, the multiprotein system responsible for genome duplication, is a highly dynamic complex displaying a large number of different enzyme activities. Recently, the

Indexed as

Cell Cycle ProteinsDNA-Binding ProteinsDNA, FungalDNA ReplicationMinichromosome Maintenance ProteinsMultiprotein ComplexesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCell Cycle ProteinsCsm3p protein, S cerevisiaeDNA-Binding ProteinsDNA, FungalMCM10 protein, S cerevisiaeMinichromosome Maintenance ProteinsMultiprotein ComplexesSaccharomyces cerevisiae ProteinsTOF1 protein, S cerevisiaeCMGDNA replicationMrc1replisomesingle-molecule biophysics

Identifiers

PMID28923950
PMCPMC5635917
OpenAlexW2754218973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.