ArticleProceedings of the National Academy of Sciences of the United States of America2017
Cross-scale effects of neural interactions during human neocortical seizure activity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Paroxysmal slow waves mark ictal networks.Epilepsia · 2026Article
- Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- The sixth sense: how much does interictal intracranial EEG add to determining the focality of epileptic networks?Brain communications · 2024Article
- Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.Brain : a journal of neurology · 2023Article
- Article
- Seizure onset patterns predict outcome after stereo-electroencephalography-guided laser amygdalohippocampotomy.Epilepsia · 2023Article
- Spatiotemporal spike-centered averaging reveals symmetry of temporal and spatial components of the spike-LFP relationship during human focal seizures.Communications biology · 2023Article
- The Spatial Reach of Neuronal Coherence and Spike-Field Coupling across the Human Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- High-Frequency Oscillations and Epileptogenic Network.Current neuropharmacology · 2022Article
- Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus.Nature reviews. Neurology · 2022Review
- Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.eLife · 2022Article
- Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.Frontiers in neurology · 2022Review
- Wheels Within Wheels: Theory and Practice of Epileptic Networks.Epilepsy currents · 2021Article
- Controversies on the network theory of epilepsy: Debates held during the ICTALS 2019 conference.Seizure · 2020Review
- DC shifts, high frequency oscillations, ripples and fast ripples in relation to the seizure onset zone.Seizure · 2020Review
- Article
- Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model.Journal of neurophysiology · 2020Article
- Pathological responses to single-pulse electrical stimuli in epilepsy: The role of feedforward inhibition.The European journal of neuroscience · 2020Article
- Seizure Onset Zone Lateralization Using a Non-linear Analysis of Micro vs. Macro Electroencephalographic Recordings During Seizure-Free Stages of the Sleep-Wake Cycle From Epilepsy Patients.Frontiers in neurology · 2020Article
- Imaging epilepsy in larval zebrafish.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2020Review
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
Small-scale neuronal networks may impose widespread effects on large network dynamics. To unravel this relationship, we analyzed eight multiscale recordings of spontaneous seizures from four patients with epilepsy. During seizures, multiunit spike activity organizes into a submillimeter-sized wavefront, and this activity correlates significantly with low-frequency rhythms from electrocorticographic recordings across a 10-cm-sized neocortical network. Notably, this correlation effect is specific to the ictal wavefront and is absent interictally or from action potential activity outside the wavefront territory. To examine the multiscale interactions, we created a model using a multiscale, nonlinear system and found evidence for a dual role for feedforward inhibition in seizures: while inhibition at the wavefront fails, allowing seizure propagation, feedforward inhibition of the surrounding centimeter-scale networks is activated via long-range excitatory connections. Bifurcation analysis revealed that distinct dynamical pathways for seizure termination depend on the surrounding inhibition strength. Using our model, we found that the mesoscopic, local wavefront acts as the forcing term of the ictal process, while the macroscopic, centimeter-sized network modulates the oscillatory seizure activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.