ArticleProceedings of the National Academy of Sciences of the United States of America2017
Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers, 3 of them syntheses that pooled it.
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Who cites it
157 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Natural killer cells in preeclampsia: an overview of current research.Frontiers in immunology · 2026Pooled it
- The influence of embryo stage on obstetric complications and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Current approaches and developments in transcript profiling of the human placenta.Human reproduction update · 2020Pooled it
- Hormonal regulation of mitochondrial dynamics- and mitophagy-related marker expression in the endometrium and placenta.Histochemistry and cell biology · 2026Article
- Gene regulation at the early human maternal-fetal interface.Nature reviews. Genetics · 2026Review
- Type V Collagen Controls Decidual Extracellular Matrix Organization and Angiogenesis During Embryo Implantation.bioRxiv : the preprint server for biology · 2026Article
- Preimplantation exposure to viral dsRNA impairs decidualization leading to altered placental development and fetal growth restriction.Reproduction & fertility · 2026Article
- Targeting the GSK-3β/mTOR axis: a novel pharmacological strategy for preeclampsia prevention and treatment.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Decidualization potential of endometrial mesenchymal stem cells and their role in reproductive health.Reproductive biology and endocrinology : RB&E · 2026Review
- Multi-omics biomarkers in female fertility: from oocyte quality to endometrial receptivity and clinical translation.Biomarker research · 2026Review
- Distinct decidualization and senomorphic responses in endometrial vs. menstrual blood stem/stromal cells: implications for reproductive therapies.Stem cell research & therapy · 2026Article
- Aspirin enhances endometrial decidualization markers in vitro among women with and without endometriosis.Reproduction & fertility · 2026Article
- The recent advancements of single-cell RNA sequencing in pre-eclampsia.Frontiers in medicine · 2026Review
- L-kynurenine or nicotinamide supplementations mitigate uterine decidualization impairments during early pregnancy of uninephrectomized mice.Frontiers in physiology · 2026Article
- Progesterone signaling in cardio-renal physiology and pathophysiology.Frontiers in endocrinology · 2026Review
- Single-cell mapping of maternal-fetal cross-talk in preeclampsia.Research square · 2025Article
- Engineering human endometrial model systems in reproductive health and disease.npj biomedical innovations · 2025Review
- Chemokines in Pregnancy.Biomolecules · 2025Review
- The Etiopathogenesis of Preeclampsia: Where Do We Stand Now?Journal of clinical medicine · 2025Review
- Maternal plasma cell-free RNA as a predictor of early and late-onset preeclampsia throughout pregnancy.Nature communications · 2025Article
97 more citing papers are in PubMed but not listed here.
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Abstract
In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by severe PE (sPE). Compared with control cells, they failed to decidualize in vitro as demonstrated by morphological criteria and the analysis of stage-specific antigens (i.e., IGFBP1, PRL). These results were bolstered by global transcriptional profiling data that showed they were transcriptionally inert. Additionally, we used laser microdissection to isolate the decidua from tissue sections of the maternal-fetal interface in sPE. Global transcriptional profiling revealed defects in gene expression. Also, decidual cells from patients with sPE, which dedifferentiated in vitro, failed to redecidualize in culture. Conditioned medium from these cells failed to support CTB invasion. To mimic aspects of the uterine environment in normal pregnancy, we added PRL and IGFBP1, which enhanced invasion. These data suggested that failed decidualization is an important contributor to down-regulated CTB invasion in sPE. Future studies will be aimed at determining whether this discovery has translational potential with regard to assessing a woman's risk of developing this pregnancy complication.
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