Evidence map›Paper›PMID 28923873›Full record

ArticleAntimicrobial agents and chemotherapy2017

An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections.

Martina Koeva, Alina D Gutu, Wesley Hebert, Jeffrey D Wager, Lael M Yonker, George A O'Toole, Frederick M Ausubel, Samuel M Moskowitz, Diane Joseph-McCarthy

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Mini review: Persister cell control strategies.Frontiers in pharmacology · 2025
    Review
  6. Mitomycin C as an Anti-Persister Strategy againstAntibiotics (Basel, Switzerland) · 2024
    Article
  7. Quorum-sensing regulation of phenazine production heightensAntimicrobial agents and chemotherapy · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Bioenergetic Inhibitors: Antibiotic Efficacy and Mechanisms of Action inFrontiers in cellular and infection microbiology · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Martina KoevaEnBiotix, Inc., Cambridge, Massachusetts, USA.
Alina D GutuDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Wesley HebertDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Jeffrey D WagerEnBiotix, Inc., Cambridge, Massachusetts, USA.
Lael M YonkerDepartment of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
George A O'TooleDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Frederick M AusubelDepartment of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Samuel M MoskowitzDepartment of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.
Diane Joseph-McCarthyEnBiotix, Inc., Cambridge, Massachusetts, USA diane.j-m@enbiotix.com.ORCID 0000-0001-9685-6177
EnBiotix (United States) · USHarvard University · USDartmouth College · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacterial persisters are a quasidormant subpopulation of cells that are tolerant to antibiotic treatment. The combination of the aminoglycoside tobramycin with fumarate as an antibacterial potentiator utilizes an antipersister strategy that is aimed at reducing recurrent

Indexed as

Anti-Bacterial AgentsAzithromycinBiofilmsCystic FibrosisDrug Resistance, BacterialDrug Therapy, CombinationFumaratesHumansMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsSputumTobramycinAnti-Bacterial AgentsAzithromycinFumaratesTobramycinaminoglycosidebacterial metabolitebacterial persistencecystic fibrosisfumaratepersistent infectionpersisterspotentiatorPseudomonas aeruginosatobramycin

Identifiers

PMID28923873
PMCPMC5700368
OpenAlexW2755569089

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.