Evidence map›Paper›PMID 28923824›Full record

ArticleThe EMBO journal2017

Snapin promotes HIV-1 transmission from dendritic cells by dampening TLR8 signaling.

Elham Khatamzas, Madeleine Maria Hipp, Daniel Gaughan, Tica Pichulik, Alasdair Leslie, Ricardo A Fernandes, Daniele Muraro, Sarah Booth, Kieran Zausmer, Mei-Yi Sun and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. The Relevance of TLR8 in Viral Infections.Pathogens (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Infection and atherosclerosis: TLR-dependent pathways.Cellular and molecular life sciences : CMLS · 2020
    Review
  6. Article
  7. Review
  8. Review
  9. Nanos genes and their role in development and beyond.Cellular and molecular life sciences : CMLS · 2018
    Review
  10. Viruses Seen by Our Cells: The Role of Viral RNA Sensors.Journal of immunology research · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Elham KhatamzasMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Madeleine Maria HippMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Daniel GaughanMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Tica PichulikMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Alasdair LeslieKwaZulu-Natal Research Institute for TB & HIV, Durban, South Africa.
Ricardo A FernandesMolecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.
Daniele MuraroMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Sarah BoothImmunology & Immunotherapy, College of Medical & Dental Sciences, University of Birmingham, Birmingham, UK.
Kieran ZausmerMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Mei-Yi SunMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Benedikt KesslerKwaZulu-Natal Research Institute for TB & HIV, Durban, South Africa.
Sarah Rowland-JonesNuffield Department of Clinical Medicine, University of Oxford NDMRB, Oxford, UK.
Vincenzo CerundoloMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK.
Alison SimmonsMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, Oxford University, Oxford, UK alison.simmons@imm.ox.ac.uk.ORCID 0000-0003-3454-0710
University of Oxford · GBBirmingham Dental Hospital · GBStanford University · US

Funding

Cancer Research UK 11331Cancer Research UK 17722Department of Health NIHR-RP-R3-12-026Medical Research Council MC_UU_00008/1Medical Research Council MC_UU_00008/7Medical Research Council MC_UU_12010/1Medical Research Council MC_UU_12010/7Wellcome TrustWellcome Trust 102974/Z/13/2
6 · The paper itself

Abstract

HIV-1 traffics through dendritic cells (DCs) en route to establishing a productive infection in T lymphocytes but fails to induce an innate immune response. Within DC endosomes, HIV-1 somehow evades detection by the pattern-recognition receptor (PRR) Toll-like receptor 8 (TLR8). Using a phosphoproteomic approach, we identified a robust and diverse signaling cascade triggered by HIV-1 upon entry into human DCs. A secondary siRNA screen of the identified signaling factors revealed several new mediators of HIV-1

Indexed as

Host-Pathogen InteractionsSignal TransductionCD4-Positive T-LymphocytesCell LineDendritic CellsHIV-1HumansToll-Like Receptor 8Vesicular Transport ProteinsSNAPIN protein, humanTLR8 protein, humanToll-Like Receptor 8Vesicular Transport ProteinsHIV‐1 and dendritic cellsHIV‐1 transmissionSnapin and vesicular traffickingTLR8 sensing

Identifiers

PMID28923824
PMCPMC5641917
OpenAlexW2755378115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.