ArticleCirculation research2017
P2Y
Open access · bronzeAbstract readComparative Study
In one paragraph
Article in Circulation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Knowledge domain and evolutionary trends of P2Y receptors in cardiovascular diseases: a bibliometric and altmetric analysis.Frontiers in pharmacology · 2025Pooled it
- Purinergic Receptor P2Y2 Regulates Neurogenesis and Functional Recovery Following Spinal Cord Injury in Zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- P2YInternational journal of molecular sciences · 2025Review
- The effects of YAP/TAZ in cardiomyocytes: a scoping review.Molecular biology reports · 2025Article
- The Hippo signalling pathway in bone homeostasis: Under the regulation of mechanics and aging.Cell proliferation · 2024Review
- Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration.Journal of nanobiotechnology · 2023Article
- YAP/TAZ: Molecular pathway and disease therapy.MedComm · 2023Review
- Therapeutic potential for P2YPurinergic signalling · 2023Review
- P2Y1R and P2Y2R: potential molecular triggers in muscle regeneration.Purinergic signalling · 2023Review
- Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor.Cell discovery · 2022Article
- Mechanosensing and the Hippo Pathway in Microglia: A Potential Link to Alzheimer's Disease Pathogenesis?Cells · 2021Review
- Metabolic regulation in the immune response to cancer.Cancer communications (London, England) · 2021Review
- From purines to purinergic signalling: molecular functions and human diseases.Signal transduction and targeted therapy · 2021Review
- Cancer-associated adipocytes as immunomodulators in cancer.Biomarker research · 2021Review
- Integration of Hippo-YAP Signaling with Metabolism.Developmental cell · 2020Review
- The Hippo Pathway in Cardiac Regeneration and Homeostasis: New Perspectives for Cell-Free Therapy in the Injured Heart.Biomolecules · 2020Review
- Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration.Seminars in cell & developmental biology · 2020Review
- Purinergic P2YCellular and molecular life sciences : CMLS · 2020Article
- Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology.International journal of biological sciences · 2020Review
- Role of YAP/TAZ in Cell Lineage Fate Determination and Related Signaling Pathways.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 1 institution in 1 country.
Farid G KhalafallaFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Steven GreeneFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Hashim KhanFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Kelli IlvesFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Megan M MonsantoFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Roberto AlvarezFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Monica ChavarriaFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Jonathan NguyenFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Benjamin NormanFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Walter P DembitskyFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.).
Mark A SussmanFrom the SDSU Heart Research Institute, San Diego State University, CA (F.G.K., S.G., H.K., K.I., M.M.M., R.A., M.C., J.N., B.N., M.A.S.); and Sharp Memorial Hospital, San Diego, CA (W.P.D.). heartman4ever@icloud.com.
Sharp Memorial Hospital · US
Funding
Surgery, Physiology and ImmunohistopathologyP01HL085577 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2006 to 2017
$18.4MRegulation of Signal Transduction to Treat Heart FailureR01HL067245 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2001 to 2021
$6.0MStem Cell Signaling in the Pathologically Challenged MyocardiumR37HL091102 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2008 to 2017
$3.8MBeta-adrenergic signaling: double edged sword of myocardial repairR01HL117163 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2013 to 2017
$1.9MAntagonism of myocardial aging and senescence with Pim-1 kinaseR01HL105759 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2011 to 2015
$1.8MResolving myocardial regeneration by tracking commitment of c-Kit+ cellsR01HL135661 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI GUDE, NATALIE ALLEN, SUSSMAN, MARK ALAN · 2017 to 2020
$1.7MEnhanced Myocardial Repair with CardioClusters and CardioChimerasR01HL122525 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2014 to 2017
$1.5MCardioprotection by optimizing mTOR activityR01HL113647 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2013 to 2016
$1.5MMolecular Engineering of Damaged Myocardium To Enhance Regeneration And RepairR01HL113656 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI SUSSMAN, MARK ALAN · 2012 to 2013
$667kEmpowering Cardiac Progenitor Cell-Mediated Repair of Injured Myocardium by Overexpressing P2Y2 Nucleotide ReceptorF32HL131299 · NHLBI · SAN DIEGO STATE UNIVERSITY · PI KHALAFALLA, FARID · 2016 to 2017
$112kNHLBI NIH HHS F32 HL131299NHLBI NIH HHS P01 HL085577NHLBI NIH HHS R01 HL067245NHLBI NIH HHS R01 HL105759NHLBI NIH HHS R01 HL113647NHLBI NIH HHS R01 HL113656NHLBI NIH HHS R01 HL117163NHLBI NIH HHS R01 HL122525NHLBI NIH HHS R01 HL135661NHLBI NIH HHS R37 HL091102
Abstract
rationaleAutologous stem cell therapy using human c-Kit
objectiveTo improve hCPC proliferation and migration responses that are critical for regeneration by targeting proregenerative P2Y METHODS AND
resultsc-Kit
conclusionsProliferation and migration of functionally impaired hCPCs are enhanced by P2Y
Indexed as
Cell ProliferationSignal TransductionAdaptor Proteins, Signal TransducingAdenosine TriphosphateAdult Stem CellsAgedAged, 80 and overCell MovementCells, CulturedFemaleGene Expression RegulationHippo Signaling PathwayHumansKineticsMaleMiddle AgedAdaptor Proteins, Signal TransducingAdenosine TriphosphateP2RY2 protein, humanPhosphoproteinsProtein Serine-Threonine KinasesProto-Oncogene Proteins c-kitPurinergic P2Y Receptor AgonistsReceptors, Purinergic P2Y2Transcription FactorsUridine TriphosphateYAP1 protein, humanYAP-Signaling Proteinsadult stem cellsheart failurenucleotides
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.