Evidence map›Paper›PMID 28923503›Full record

ArticleThe ocular surface2018

In vivo confocal microscopy detects bilateral changes of corneal immune cells and nerves in unilateral herpes zoster ophthalmicus.

Bernardo M Cavalcanti, Andrea Cruzat, Afsun Sahin, Deborah Pavan-Langston, Eric Samayoa, Pedram Hamrah

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ocular surface, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

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  13. Corneal deposits and nerve alterations in Bietti Corneoretinal Crystalline Dystrophy imaged using in vivo confocal microscopy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
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  18. Three-dimensionalFrontiers in medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Bernardo M CavalcantiOcular Surface Imaging Center and Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA; Post-Graduate Program, Surgery Department, Pernambuco Federal University (UFPE), Recife, PE, Brazil.
Andrea CruzatOcular Surface Imaging Center and Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Afsun SahinOcular Surface Imaging Center and Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA; Koc University Medical School, Research Center for Translational Medicine, Istanbul, Turkey; Boston Image Reading Center, Tufts University School of Medicine, Boston, MA, USA.
Deborah Pavan-LangstonOcular Surface Imaging Center and Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Eric SamayoaOcular Surface Imaging Center and Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.
Pedram HamrahOcular Surface Imaging Center and Cornea & Refractive Surgery Service, Massachusetts Eye & Ear Infirmary, Department of Ophthalmology, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA; Boston Image Reading Center, Tufts University School of Medicine, Boston, MA, USA; Cornea Service, New England Eye Center, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA. Electronic address: pedram.hamrah@tufts.edu.
Harvard University · USMassachusetts Eye and Ear Infirmary · USImaging Center · USUniversidade Federal de Pernambuco · BR

Funding

The role of plasmacytoid dendritic cells in corneal immunityR01EY022695 · NEI · TUFTS MEDICAL CENTER · PI HAMRAH, PEDRAM · 2013 to 2017
$2.4M
Immunobiology of Corneal Antigen-Presenting CellsK08EY020575 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI HAMRAH, PEDRAM · 2010 to 2013
$914k
Role of plasmacytoid dendritic cells in corneal nerve health and regenerationR21EY025393 · NEI · TUFTS MEDICAL CENTER · PI HAMRAH, PEDRAM · 2016 to 2017
$454k
NEI NIH HHS K08 EY020575NEI NIH HHS R01 EY022695NEI NIH HHS R21 EY025393
6 · The paper itself

Abstract

purposeTo analyze bilateral corneal immune cell and nerve alterations in patients with unilateral herpes zoster ophthalmicus (HZO) by laser in vivo confocal microscopy (IVCM) and their correlation with corneal sensation and clinical findings. MATERIALS AND

methodsThis is a prospective, cross-sectional, controlled, single-center study. Twenty-four eyes of 24 HZO patients and their contralateral clinically unaffected eyes and normal controls (n = 24) were included. Laser IVCM (Heidelberg Retina Tomograph/Rostock Cornea Module), corneal esthesiometry (Cochet-Bonnet) were performed. Changes in corneal dendritiform cell (DC) density and morphology, number and length of subbasal nerve fibers and their correlation to corneal sensation, pain, lesion location, disease duration, and number of episodes were analyzed.

resultsHZO-affected and contralateral eyes showed a significant increase in DC influx of the central cornea as compared to controls (147.4 ± 33.9, 120.1 ± 21.2, and 23.0 ± 3.6 cells/mm2; p < 0.0001). In HZO eyes DCs were larger in area (319.4 ± 59.8 μm

conclusionsChronic unilateral HZO causes significant bilateral increase in corneal DC density and decrease of the corneal subbasal nerves as compared to controls. Negative correlation was observed for DC density and size to nerve parameters, suggesting interplay between the immune and nervous systems. Patients with chronic pain also showed increased nerve beading and activated DCs.

Indexed as

Cell CountCorneaCranial Nerve DiseasesCross-Sectional StudiesDendritic CellsFemaleHerpes Zoster OphthalmicusHumansMaleMicroscopy, ConfocalMiddle AgedNerve FibersOphthalmic NerveProspective StudiesSensationConfocal microscopyCorneal nervesCorneal sensationDendritic cellsHerpes zoster ophthalmicusNeurotrophic keratopathy

Identifiers

PMID28923503
PMCPMC5756670
OpenAlexW2755024787

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.