Evidence map›Paper›PMID 28923102›Full record

ArticleJournal for immunotherapy of cancer2017

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer.

Andrew Zloza, A Karolina Palucka, Lisa M Coussens, Philip J Gotwals, Mark B Headley, Elizabeth M Jaffee, Amanda W Lund, Arlene H Sharpe, Mario Sznol, Derek A Wainwright and 2 more

Abstract readConference Proceedings
In one paragraph

Article in Journal for immunotherapy of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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  8. UVB mutagenesis differs inLife science alliance · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew ZlozaRutgers Cancer Institute of New Jersey and Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.
A Karolina PaluckaThe Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.
Lisa M CoussensKnight Cancer Institute at Oregon Health & Science University, Portland, OR, 97239, USA.
Philip J GotwalsNovartis Institutes for BioMedical Research, Inc., Cambridge, MA, 02139, USA.
Mark B HeadleyUniversity of California San Francisco, San Francisco, CA, 94143, USA.
Elizabeth M JaffeeSidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, 21287, USA.
Amanda W LundOregon Health & Science University, Portland, OR, 97239, USA.
Arlene H SharpeHarvard Medical School, Boston, MA, 02115, USA.
Mario SznolYale School of Medicine, New Haven, CT, 06520, USA.
Derek A WainwrightDepartment of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Kwok-Kin WongDana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA.
Marcus W BosenbergYale School of Medicine, 15 York Street, St LMP 5031, New Haven, CT, 06510, USA. marcus.bosenberg@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9M
Congenic Mouse Medels of Melanoma for the Characterization of Tumor Immune ResponsesR01CA196660 · NCI · YALE UNIVERSITY · PI BOSENBERG, MARCUS W · 2016 to 2018
$1.7M
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA196660
6 · The paper itself

Abstract

Understanding how murine models can elucidate the mechanisms underlying antitumor immune responses and advance immune-based drug development is essential to advancing the field of cancer immunotherapy. The Society for Immunotherapy of Cancer (SITC) convened a workshop titled, "Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy" as part of the SITC 31st Annual Meeting and Associated Programs on November 10, 2016 in National Harbor, MD. The workshop focused on key issues in optimizing models for cancer immunotherapy research, with discussions on the strengths and weaknesses of current models, approaches to improve the predictive value of mouse models, and advances in cancer modeling that are anticipated in the near future. This full-day program provided an introduction to the most common immunocompetent and humanized models used in cancer immunology and immunotherapy research, and addressed the use of models to evaluate immune-targeting therapies. Here, we summarize the workshop presentations and subsequent panel discussion.

Indexed as

Disease Models, AnimalAnimalsHumansImmunotherapyMiceMolecular Targeted TherapyNeoplasmsSocieties, ScientificTumor MicroenvironmentCancer immunotherapyHumanized mouseImmunocompetentMouse-in-mouseMouse modelsTumor microenvironment

Identifiers

PMID28923102
PMCPMC5604351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.