ArticleMolecular neurodegeneration2017
Whole blood gene expression and white matter Hyperintensities.
Article in Molecular neurodegeneration, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Joint Associations of Cardiometabolic Multimorbidity and Depressive Symptoms on Cognitive Function Among Chinese Middle-Aged and Older Adults.Neuropsychiatric disease and treatment · 2026Article
- A cross-sectional study on white matter hyperitensity in patients at the initial diagnosis of neuropsychiatric SLE: Correlation with Clinical and Laboratory Findings.Clinical rheumatology · 2025Article
- Impact of perinatal factors on T cells and transcriptomic changes in preterm infant brain injury.Journal of neuroinflammation · 2024Article
- Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities.Journal of stroke · 2024Review
- Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer's disease.Frontiers in neurology · 2024Article
- SiGra: single-cell spatial elucidation through an image-augmented graph transformer.Nature communications · 2023Article
- Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI.Brain : a journal of neurology · 2023Article
- CovInter: interaction data between coronavirus RNAs and host proteins.Nucleic acids research · 2023Article
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- Pro-inflammatory Monocyte Phenotype During Acute Progression of Cerebral Small Vessel Disease.Frontiers in cardiovascular medicine · 2021Article
- The Associations ofFrontiers in genetics · 2019Article
- Cardiovascular disease and brain health: Focus on white matter hyperintensities.International journal of cardiology. Heart & vasculature · 2018Review
- DNA Methylation Profiling Reveals the Change of Inflammation-AssociatedFrontiers in aging neuroscience · 2018Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundWhite matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of white matter lesions however, remains uncertain. The characterization of gene expression profiles associated with WMH might help uncover molecular mechanisms underlying WMH.
methodsWe performed a transcriptome-wide association study of gene expression profiles with WMH in 3248 participants from the Framingham Heart Study using the Affymetrix Human Exon 1.0 ST Array.
resultsWe identified 13 genes that were significantly associated with WMH (FDR < 0.05) after adjusting for age, sex and blood cell components. Many of these genes are involved in inflammation-related pathways.
conclusionThirteen genes were significantly associated with WMH. Our study confirms the hypothesis that inflammation might be an important factor contributing to white matter lesions. Future work is needed to explore if these gene products might serve as potential therapeutic targets.
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