Evidence map›Paper›PMID 28922871›Full record

ArticleGenome biology and evolution2017

Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus.

Qing Li, Neda Barghi, Aiping Lu, Alexander E Fedosov, Pradip K Bandyopadhyay, Arturo O Lluisma, Gisela P Concepcion, Mark Yandell, Baldomero M Olivera, Helena Safavi-Hemami

Abstract read
In one paragraph

Article in Genome biology and evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  2. Article
  3. Review
  4. Article
  5. Prey Shifts Drive Venom Evolution in Cone Snails.Molecular biology and evolution · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Comparative Venomics ofMarine drugs · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qing LiEccles Institute of Human Genetics, University of Utah.
Neda BarghiMarine Science Institute, University of the Philippines-Diliman, Quezon City, Philippines.
Aiping LuSchool of Life Sciences and Technology, Tongji University, Shanghai, China.
Alexander E FedosovA.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Science, Moscow, Russia.
Pradip K BandyopadhyayDepartment of Biology, University of Utah.
Arturo O LluismaMarine Science Institute, University of the Philippines-Diliman, Quezon City, Philippines.
Gisela P ConcepcionMarine Science Institute, University of the Philippines-Diliman, Quezon City, Philippines.
Mark YandellEccles Institute of Human Genetics, University of Utah.
Baldomero M OliveraDepartment of Biology, University of Utah.
Helena Safavi-HemamiDepartment of Biology, University of Utah.

Funding

Venoms, Biological Resources, Molecular BiologyP01GM048677 · NIGMS · UNIVERSITY OF UTAH · PI BANDYOPADHYAY, PRADIP K · 1993 to 2018
$32.2M
Diverse drug lead compounds from bacterial symbionts in tropical marine mollusksU01TW008163 · FIC · OREGON HEALTH & SCIENCE UNIVERSITY · PI HAYGOOD, MARGO GENEVIEVE · 2008 to 2013
$4.3M
Genomics-based Venom Studies Using the Cone Snail C. BullatusR01GM099939 · NIGMS · UNIVERSITY OF UTAH · PI YANDELL, MARK DOUGLAS · 2012 to 2015
$1.1M
FIC NIH HHS U01 TW008163NIGMS NIH HHS P01 GM048677NIGMS NIH HHS R01 GM099939
6 · The paper itself

Abstract

The genus Conus comprises approximately 700 species of venomous marine cone snails that are highly efficient predators of worms, snails, and fish. In evolutionary terms, cone snails are relatively young with the earliest fossil records occurring in the Lower Eocene, 55 Ma. The rapid radiation of cone snail species has been accompanied by remarkably high rates of toxin diversification. To shed light on the molecular mechanisms that accompany speciation, we investigated the toxin repertoire of two sister species, Conus andremenezi and Conus praecellens, that were until recently considered a single variable species. A total of 196 and 250 toxin sequences were identified in the venom gland transcriptomes of C. andremenezi and C. praecellens belonging to 25 and 29 putative toxin gene superfamilies, respectively. Comparative analysis with closely (Conus tribblei and Conus lenavati) and more distantly related species (Conus geographus) suggests that speciation is associated with significant diversification of individual toxin genes (exogenes) whereas the expression pattern of toxin gene superfamilies within lineages remains largely conserved. Thus, changes within individual toxin sequences can serve as a sensitive indicator for recent speciation whereas changes in the expression pattern of gene superfamilies are likely to reflect more dramatic differences in a species' interaction with its prey, predators, and competitors.

Indexed as

TranscriptomeAmino Acid SequenceAnimalsConotoxinsConus SnailPhylogenySequence AlignmentSpecies SpecificityConotoxinsconotoxinsexogenesspeciationvenom evolution

Identifiers

PMID28922871
PMCPMC5604253

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.