ArticleJournal of experimental botany2017
The meiotic regulator JASON utilizes alternative translation initiation sites to produce differentially localized forms.
Article in Journal of experimental botany, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Meiotic cytokinesis defects in cultured Arabidopsis flowers induce diploid microspores.Plant reproduction · 2025Article
- Duckweed genomes and epigenomes underlie triploid hybridization and clonal reproduction.Current biology : CB · 2025Article
- Identification of two mutant JASON-RELATED genes associated with unreduced pollen production in potato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Haploid male fertility is restored by parallel spindle genes in Arabidopsis thaliana.Nature plants · 2023Article
- A simple and rapid method for imaging male meiotic cells in anthers of model and non-model plant species.Plant reproduction · 2021Article
- Gene Duplication Accelerates the Pace of Protein Gain and Loss from Plant Organelles.Molecular biology and evolution · 2020Article
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8 authors.
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Abstract
The JASON (JAS) protein plays an important role in maintaining an organelle band across the equator of male meiotic cells during the second division, with its loss leading to unreduced pollen in Arabidopsis. In roots cells, JAS localizes to the Golgi, tonoplast and plasma membrane. Here we explore the mechanism underlying the localization of JAS. Overall, our data show that leaky ribosom scanning and alternative translation initiation sites (TISs) likely leads to the formation of two forms of JAS: a long version with an N-terminal Golgi localization signal and a short version with a different N-terminal signal targeting the protein to the plasma membrane. The ratio of the long and short forms of JAS is developmentally regulated, with both being produced in roots but the short form being predominant and functional during meiosis. This regulation of TISs in meiocytes ensures that the short version of JAS is formed during meiosis to ensure separation of chromosome groups and the production of reduced pollen. We hypothesize that increased occurrence of unreduced pollen under stress conditions may be a consequence of altered usage of JAS TISs during stress.
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