Evidence map›Paper›PMID 28922562›Full record

ArticleThoracic cancer2017

Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer.

Seung Soo Yoo, Mi Jeong Hong, Jang Hyuck Lee, Jin Eun Choi, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Yangki Seok, Eungbae Lee and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Seung Soo YooDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Mi Jeong HongCell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jang Hyuck LeeDepartment of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jin Eun ChoiCell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu, South Korea.
Shin Yup LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Jaehee LeeDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Seung Ick ChaDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Chang Ho KimDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Yangki SeokDepartment of Thoracic Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
Eungbae LeeDepartment of Thoracic Surgery, School of Medicine, Kyungpook National University, Daegu, South Korea.
Sukki ChoDepartment of Thoracic and Cardiovascular Surgery, School of Medicine, Seoul National University, Seoul, South Korea.
Sanghoon JheonDepartment of Thoracic and Cardiovascular Surgery, School of Medicine, Seoul National University, Seoul, South Korea.
Jae Yong ParkDepartment of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
Kyungpook National University · KRNational University · SDNew Generation University College · ETSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A high-throughput mapping method of RNA-RNA interactions by crosslinking, ligation, and sequencing of hybrids (CLASH) can not only provide information about canonical but also non-canonical interactions. We evaluated the associations between variants in microRNA target sites using CLASH data and survival outcomes of 782 early-stage non-small cell lung cancer (NSCLC) patients who underwent curative surgical resection. Among the 100 variants studied, two variants showed significant association with survival outcomes. The POLR2A rs2071504 C > T variant was associated with poor overall and disease-free survival under a dominant model (hazard ratio [HR] 1.42, 95% confidence interval [CI] 1.08-1.88; P = 0.01 and HR 1.34, 95% CI 1.08-1.67; P = 0.01, respectively). Patients carrying the NR2F6 rs2288539 TT genotype showed significantly better overall survival than those with the NR2F6 rs2288539 CC or CT genotypes (HR 0.13, 95% CI 0.02-0.90; P = 0.04). These findings suggest that POLR2A rs2071504 C > T and NR2F6 rs2288539 C > T can influence prognosis in early-stage NSCLC patients.

Indexed as

Polymorphism, Single NucleotideBinding SitesCarcinoma, Non-Small-Cell LungDisease-Free SurvivalDNA-Directed RNA PolymerasesFemaleGenetic Association StudiesHumansKaplan-Meier EstimateLung NeoplasmsMaleMicroRNAsNeoplasm StagingPrognosisReceptors, SteroidRepressor ProteinsDNA-Directed RNA PolymerasesMicroRNAsNR2F6 protein, humanPOLR2A RNA polymerase, humanReceptors, SteroidRepressor ProteinsmiRNA target sitenon-small cell lung cancerpolymorphismsurvival outcome

Identifiers

PMID28922562
PMCPMC5668488
OpenAlexW2754944769

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.