Evidence map›Paper›PMID 28922542›Full record

ArticleJournal of cellular and molecular medicine2018

A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells.

Marta Díaz, Roncesvalles González, Daniel Plano, Juan Antonio Palop, Carmen Sanmartín, Ignacio Encío

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Marta DíazDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Roncesvalles GonzálezDepartamento de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Spain.
Daniel PlanoDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Juan Antonio PalopDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Carmen SanmartínDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.
Ignacio EncíoDepartamento de Ciencias de la Salud, Universidad Pública de Navarra, Pamplona, Spain.ORCID 0000-0003-1732-1989
Navarre Institute of Health Research · ESUniversidad Publica de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Symmetric aromatic diselenides are potential anticancer agents with strong cytotoxic activity. In this study, the in vitro anticancer activities of a novel series of diarylseleno derivatives from the diphenyldiselenide (DPDS) scaffold were evaluated. Most of the compounds exhibited high efficacy for inducing cytotoxicity against different human cancer cell lines. DPDS 2, the compound with the lowest mean GI

Indexed as

ApoptosisAutophagyBenzene DerivativesCaspasesCell Cycle CheckpointsCell Line, TumorEnzyme ActivationHumansJNK Mitogen-Activated Protein KinasesLung NeoplasmsOrganoselenium CompoundsBenzene DerivativesCaspasesdiphenyldiselenideJNK Mitogen-Activated Protein KinasesOrganoselenium CompoundsautophagydiphenyldiselenideJNKp38 MAPKp53

Identifiers

PMID28922542
PMCPMC5742718
OpenAlexW2754981397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.