Evidence map›Paper›PMID 28922497›Full record

ArticleMolecular microbiology2017

Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus.

Omar Loss, Margherita Bertuzzi, Yu Yan, Natalie Fedorova, Bethany L McCann, Darius Armstrong-James, Eduardo A Espeso, Nick D Read, William C Nierman, Elaine M Bignell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Omar LossMicrobiology Section, Centre for Molecular Microbiology and Infection, Imperial College London, London SW7 2AZ, UK.
Margherita BertuzziManchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester M13 9NT, UK.
Yu YanThe J. Craig Venter Institute, Infectious Diseases Program, Rockville, MD, USA.
Natalie FedorovaThe J. Craig Venter Institute, Infectious Diseases Program, Rockville, MD, USA.
Bethany L McCannManchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester M13 9NT, UK.
Darius Armstrong-JamesFungal Pathogens Laboratory, National Heart and Lung Institute, Imperial College London SW7 2AY, UK.
Eduardo A EspesoDepartment of Molecular and Cellular Biology, Centro de Investigaciones Biologicas (C.S.I.C.), Madrid, Spain.
Nick D ReadManchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester M13 9NT, UK.
William C NiermanThe J. Craig Venter Institute, Infectious Diseases Program, Rockville, MD, USA.
Elaine M BignellManchester Fungal Infection Group, Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester M13 9NT, UK.ORCID http://orcid.org/0000-0001-7748-1920
University of Manchester · GBJ. Craig Venter Institute · USCentro de Investigaciones Biológicas Margarita Salas · ESImperial College London · GBLung Institute · US

Funding

Biotechnology and Biological Sciences Research Council BB/G009619/1Medical Research Council G0501164Medical Research Council MC_PC_15072Medical Research Council MR/L000822/1Medical Research Council MR/M02010X/1Wellcome Trust
6 · The paper itself

Abstract

Functional coupling of calcium- and alkaline responsive signalling occurs in multiple fungi to afford efficient cation homeostasis. Host microenvironments exert alkaline stress and potentially toxic concentrations of Ca

Indexed as

Antifungal AgentsAspergillus fumigatusAspergillus nidulansCalcineurinCalciumCalcium SignalingFungal ProteinsGene Expression ProfilingGene Expression Regulation, FungalHost-Pathogen InteractionsHumansHydrogen-Ion ConcentrationLoss of Function MutationSodium-Potassium-Exchanging ATPaseTranscription FactorsAntifungal AgentsCalcineurinCalciumCrzA protein, Aspergillus fumigatusFungal ProteinsPacC protein, AspergillusSodium-Potassium-Exchanging ATPaseTranscription Factors

Identifiers

PMID28922497
PMCPMC5725717
OpenAlexW2756413595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.