ArticlePloS one2017
Cesarean section without medical indication and risk of childhood asthma, and attenuation by breastfeeding.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Risk factors of asthma in the Asian population: a systematic review and meta-analysis.Journal of physiological anthropology · 2021Pooled it
- Association of cesarean section with asthma and atopic dermatitis in infants from the Japan Environment and Children's Study.Scientific reports · 2025Article
- The Early Appearance of Asthma and Its Relationship with Gut Microbiota: A Narrative Review.Microorganisms · 2024Review
- Personalized Nutrition with Banked Human Milk for Early Gut Microbiota Development: In Pursuit of the Perfect Match.Nutrients · 2024Review
- Evaluation of Childhood Allergy Risk Among Pregnant Women in a Tertiary Care Hospital in Thailand.Cureus · 2024Article
- Asthma, classical conditioning, and the autonomic nervous system - a hypothesis for why children wheeze.Archives of disease in childhood · 2024Review
- A Higher Maternal Education Level Could Be a Critical Factor in the Exceeded Cesarean Section Delivery in Indonesia.Iranian journal of public health · 2024Article
- Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions.Nutrients · 2023Review
- Review
- Review
- Periconceptional folic acid supplementation is a risk factor for childhood asthma: a case-control study.BMC pregnancy and childbirth · 2022Article
- Effective Ways to Prevent Allergic Diseases: Where Do We Stand?Handbook of experimental pharmacology · 2022Article
- S3 guideline Allergy Prevention.Allergologie select · 2022Article
- Natural history and associated early life factors of childhood asthma: a population registry-based cohort study in Denmark.BMJ open · 2021Article
- Are there adverse outcomes for child health and development following caesarean section delivery? Can we justify using elective caesarean section to prevent obstetric pelvic floor damage?International urogynecology journal · 2021Review
- Cesarean delivery on maternal request and its influencing factors in Chongqing, China.BMC pregnancy and childbirth · 2021Article
- Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case-control study.BMC pulmonary medicine · 2021Article
- A review on the effect of COVID-19 in type 2 asthma and its management.International immunopharmacology · 2021Review
- Caesarean delivery in a migration context: the role of prior delivery in the host country.Sexual and reproductive health matters · 2020Article
- Perinatal environment shapes microbiota colonization and infant growth: impact on host response and intestinal function.Microbiome · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies suggest that caesarean section (CS) may increase the risk of asthma in children, but none of them could preclude potential confounding effects of underlying medical indications for CS. We aim to assess the association between CS itself (without medical indications) and risk of childhood asthma.
methodsWe conducted a hospital-based case-control study on childhood asthma with 573 cases and 812 controls in Shanghai. Unconditional logistic regression models in SAS were employed to control for potential confounders.
resultsOur study found that CS without medical indication was significantly associated with elevated asthma risk (adjusted OR = 1.58 [95% CI 1.17-2.13]). However, this risk was attenuated in children fed by exclusive breastfeeding in the first six months after birth (adjusted OR = 1.39 [95% CI 0.92-2.10]). In contrast, the risk was more prominent in children with non-exclusive breastfeeding or bottle feeding (adjusted OR = 1.91 [95% CI 1.22-2.99]).
conclusionsCS without medical indication was associated with an increased risk of childhood asthma. Exclusive breastfeeding in infancy may attenuate this risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.