ArticleJournal of the American Chemical Society2017
Remote, Late-Stage Oxidation of Aliphatic C-H Bonds in Amide-Containing Molecules.
Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 105 citations in OpenAlex.
- Article
- Making Blank Faces Expressive: Chemical Approaches to the Modification of Chemically Inert Peptides.Journal of peptide science : an official publication of the European Peptide Society · 2026Review
- Article
- Late-Stage Oxidation of C(spAngewandte Chemie (International ed. in English) · 2025Article
- Article
- Late-stage modification of bioactive compounds: Improving druggability through efficient molecular editing.Acta pharmaceutica Sinica. B · 2024Review
- A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C-H oxidation of carbocyclicProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Allylic hydroxylation of enones useful for the functionalization of relevant drugs and natural products.Nature communications · 2023Article
- Amine Organocatalysis of Remote, Chemoselective C(spACS catalysis · 2022Article
- Copper(ii)-catalyzed and acid-promoted highly regioselective oxidation of tautomerizable C(spRSC advances · 2021Article
- C-H Activation: Toward Sustainability and Applications.ACS central science · 2021Review
- Novel Strategies in C-H Oxidations for Natural Product Diversification-A Remote Functionalization Application Summary.Frontiers in chemistry · 2021Review
- Enantioselective Michael-Proton Transfer-Lactamization for Pyroglutamic Acid Derivatives: Synthesis of Dimethyl-(Organic syntheses; an annual publication of satisfactory methods for the preparation of organic chemicals · 2021Article
- C-H Bond Functionalization of Amines: A Graphical Overview of Diverse Methods.SynOpen (2017) · 2021Article
- Competition between N and O: use of diazineChemical science · 2020Article
- Homobenzylic Oxygenation Enabled by Dual Organic Photoredox and Cobalt Catalysis.Journal of the American Chemical Society · 2020Article
- Combined Photoredox/Enzymatic C-H Benzylic Hydroxylations.Angewandte Chemie (International ed. in English) · 2019Article
- Bio-inspired iron-catalyzed oxidation of alkylarenes enables late-stage oxidation of complex methylarenes to arylaldehydes.Nature communications · 2019Article
- Chemoselective methylene oxidation in aromatic molecules.Nature chemistry · 2019Article
- Aliphatic C-H Oxidations for Late-Stage Functionalization.Journal of the American Chemical Society · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Amide-containing molecules are ubiquitous in natural products, pharmaceuticals, and materials science. Due to their intermediate electron-richness, they are not amenable to any of the previously developed N-protection strategies known to enable remote aliphatic C-H oxidations. Using information gleaned from a systematic study of the main features that makes remote oxidations of amides in peptide settings possible, we developed an imidate salt protecting strategy that employs methyl trifluoromethanesulfonate as a reversible alkylating agent. The imidate salt strategy enables, for the first time, remote, nondirected, site-selective C(sp
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.