ArticleJournal of applied clinical medical physics2017
Potential proton and photon dose degradation in advanced head and neck cancer patients by intratherapy changes.
Article in Journal of applied clinical medical physics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Towards automated dose-guided patient positioning at clinical timescale in head-and-neck cancer proton radiotherapy.Medical physics · 2026Article
- Nominal plan robustness may predict plan degradation in proton therapy for oropharyngeal head-and-neck cancer.Journal of applied clinical medical physics · 2026Article
- Triggered plan adaptation using multi-image optimization for improved robustness in head-and-neck cancer proton therapy.Physics and imaging in radiation oncology · 2025Article
- Partial adaptation for online-adaptive proton therapy triggered by during-delivery treatment verification: Feasibility study on prostate cancer treatments.Physics and imaging in radiation oncology · 2025Article
- Article
- CBCT-Based Dose Monitoring and Adaptive Planning Triggers in Head and Neck PBS Proton Therapy.Cancers · 2023Article
- Evaluating the effect of setup uncertainty reduction and adaptation to geometric changes on normal tissue complication probability using online adaptive head and neck intensity modulated proton therapy.Physics in medicine and biology · 2023Article
- Dosimetric impact of adaptive proton therapy in head and neck cancer - A review.Clinical and translational radiation oncology · 2023Review
- Pre-treatment analysis of non-rigid variations can assist robust intensity-modulated proton therapy plan selection for head and neck patients.Medical physics · 2022Article
- Review
- Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges.Cancers · 2022Review
- Onboard cone-beam CT-based replan evaluation for head and neck proton therapy.Journal of applied clinical medical physics · 2022Article
- DIR-based models to predict weekly anatomical changes in head and neck cancer proton therapy.Physics in medicine and biology · 2022Article
- Adaptive proton therapy.Physics in medicine and biology · 2021Review
- Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Article
- Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy.Physics in medicine and biology · 2021Article
- Three discipline collaborative radiation therapy special debate: All head and neck cancer patients with intact tumors/nodes should have scheduled adaptive replanning performed at least once during the course of radiotherapy.Journal of applied clinical medical physics · 2019Article
- On-line dose-guidance to account for inter-fractional motion during proton therapy.Physics and imaging in radiation oncology · 2019Article
- Intensity modulated proton therapy (IMPT) - The future of IMRT for head and neck cancer.Oral oncology · 2019Review
- Assessing Novel Drugs and Radiation Technology in the Chemoradiation of Oropharyngeal Cancer.Medicines (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEvaluation of dose degradation by anatomic changes for head-and-neck cancer (HNC) intensity-modulated proton therapy (IMPT) relative to intensity-modulated photon therapy (IMRT) and identification of potential indicators for IMPT treatment plan adaptation.
methodsFor 31 advanced HNC datasets, IMPT and IMRT plans were recalculated on a computed tomography scan (CT) taken after about 4 weeks of therapy. Dose parameter changes were determined for the organs at risk (OARs) spinal cord, brain stem, parotid glands, brachial plexus, and mandible, for the clinical target volume (CTV) and the healthy tissue outside planning target volume (PTV). Correlation of dose degradation with target volume changes and quality of rigid CT matching was investigated.
resultsRecalculated IMPT dose distributions showed stronger degradation than the IMRT doses. OAR analysis revealed significant changes in parotid median dose (IMPT) and near maximum dose (D
conclusionsThe study underlines the necessity of precise positioning and monitoring of anatomy changes, especially in IMPT which might require adaptation more often. Since OAR doses remained typically below constraints, IMPT plan adaptation will be indicated by target dose degradations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.