Evidence map›Paper›PMID 28921719›Full record

ArticleThe European journal of neuroscience2017

Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons.

Carissa D Winland, Nora Welsh, Alberto Sepulveda-Rodriguez, Stefano Vicini, Kathleen A Maguire-Zeiss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The European journal of neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Carissa D WinlandInterdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, D.C., 20007, USA.ORCID http://orcid.org/0000-0002-1394-7231
Nora WelshDepartment of Biology, Georgetown University, Washington, D.C., USA.
Alberto Sepulveda-RodriguezInterdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, D.C., 20007, USA.ORCID http://orcid.org/0000-0002-6479-8635
Stefano ViciniInterdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, D.C., 20007, USA.
Kathleen A Maguire-ZeissInterdisciplinary Program in Neuroscience, Georgetown University Medical Center, Washington, D.C., 20007, USA.
Georgetown University · US

Funding

Training in Neural Injury &PlasticityT32NS041218 · NINDS · GEORGETOWN UNIVERSITY · PI MARK P BURNS, Kathleen Anne Maguire-Zeiss · 2001 to 2026
$3.5M
PAR-1 Signaling and HANDR01NS083410 · NINDS · GEORGETOWN UNIVERSITY · PI CONANT, KATHERINE E, MAGUIRE-ZEISS, KATHLEEN ANNE · 2013 to 2017
$1.9M
Neuroinflammatory effects on striatal Ca2+-permeable AMPA and kainate receptorsF31NS092230 · NINDS · GEORGETOWN UNIVERSITY · PI BERGER, CARISSA WINLAND · 2015 to 2016
$61k
NINDS NIH HHS F31 NS092230NINDS NIH HHS R01 NS083410NINDS NIH HHS T32 NS041218
6 · The paper itself

Abstract

Neuroinflammation precedes neuronal loss in striatal neurodegenerative diseases and can be exacerbated by the release of proinflammatory molecules by microglia. These molecules can affect trafficking of AMPARs. The preferential trafficking of calcium-permeable versus impermeable AMPARs can result in disruptions of [Ca

Indexed as

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidAnimalsCalciumCalcium Channel BlockersCalcium Channels, L-TypeCations, DivalentCorpus StriatumCX3C Chemokine Receptor 1Dopaminergic NeuronsFemaleInflammationLipopolysaccharidesMaleMice, Inbred C57BLMice, TransgenicMicrogliaalpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic AcidCalciumCalcium Channel BlockersCalcium Channels, L-TypeCations, DivalentCX3C Chemokine Receptor 1Cx3cr1 protein, mouseDrd1 protein, mouseDRD2 protein, mouseLipopolysaccharidesReceptors, AMPAReceptors, Dopamine D1Receptors, Dopamine D2calcium imagingcalcium-permeable AMPARsneuroinflammationSPNVGCCs

Identifiers

PMID28921719
PMCPMC5673553
OpenAlexW2754366508

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.