ArticleInternational journal of cancer2018
Contralateral breast cancers: Independent cancers or metastases?
Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: A meta-analysis of studies from recent decade (2008-2018).Cancer medicine · 2019Pooled it
- Identifying Locally Recurrent Versus Second Primary Breast Cancer: Genomic Versus Clinical Criteria from Carolina Breast Cancer Study Phase III.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Trial
- Article
- Transcriptome predictors of second breast events in ductal carcinoma in situ: a case‒control study including Black and White women.Breast cancer research : BCR · 2026Article
- Statin use and risk of contralateral breast cancer: an updated cohort study with landmark analysis.European journal of epidemiology · 2026Article
- Genomic and spatial analysis of local recurrences following risk-adapted breast radiotherapy in the IMPORT trials.Breast cancer research : BCR · 2026Article
- Bilateral Primary Breast Cancer: Current Evidence and Future Perspectives.Breast cancer (Dove Medical Press) · 2026Review
- Contralateral breast cancer after radiotherapy and hormone therapy in two cohorts of US breast cancer survivors.British journal of cancer · 2026Article
- A case report of synchronous bilateral breast cancer with distinct histological subtypes and favorable long-term survival.Frontiers in oncology · 2026Article
- Survival analysis of metachronous bilateral ectopic breast cancer utilizing the SEER database and the pioneering construction of a nomogram model.European journal of medical research · 2025Article
- Second cancers in 475 000 women with early invasive breast cancer diagnosed in England during 1993-2016: population based observational cohort study.BMJ (Clinical research ed.) · 2025Observational
- Article
- Misclassification of second primary and recurrent breast cancer in the surveillance epidemiology and end results registry.Cancer causes & control : CCC · 2025Article
- Analysis of Shared Variants between Cancer Biospecimens.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Survival analysis for patients with metachronous contralateral breast cancer: Insights from a retrospective study.Oncology letters · 2024Article
- Risk factors of developing contralateral breast cancer after first primary breast cancer treatment.Cancer reports (Hoboken, N.J.) · 2024Article
- Patient-derived organoid elucidates the identical clonal origin of bilateral breast cancer with diverse molecular subtypes.Frontiers in oncology · 2024Article
- Omission of axillary lymph node dissection in breast cancer patients with micrometastasis or isolated tumor cells in sentinel lymph nodes: a 12-year experience in a tertiary breast unit.Journal of cancer research and clinical oncology · 2023Article
- Racial and Ethnic Disparities in Synchronous and Metachronous Bilateral Breast Cancer.Journal of racial and ethnic health disparities · 2023Article
- Caveolin-1 genotypes as predictor for locoregional recurrence and contralateral disease in breast cancer.Breast cancer research and treatment · 2023Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
A cancer in the contralateral breast in a woman with a previous or synchronous breast cancer is typically considered to be an independent primary tumor. Emerging evidence suggests that in a small subset of these cases the second tumor represents a metastasis. We sought to investigate the issue using massively parallel sequencing targeting 254 genes recurrently mutated in breast cancer. We examined the tumor archives at Memorial Sloan Kettering Cancer Center for the period 1995-2006 to identify cases of contralateral breast cancer where surgery for both tumors was performed at the Center. We report results from 49 patients successfully analyzed by a targeted massively parallel sequencing assay. Somatic mutations and copy number alterations were defined by state-of-the-art algorithms. Clonal relatedness was evaluated by statistical tests specifically designed for this purpose. We found evidence that the tumors in contralateral breasts were clonally related in three cases (6%) on the basis of matching mutations at codons where somatic mutations are rare. Clinical data and the presence of similar patterns of gene copy number alterations were consistent with metastasis for all three cases. In three additional cases, there was a solitary matching mutation at a common PIK3CA locus. The results suggest that a subset of contralateral breast cancers represent metastases rather than independent primary tumors. Massively parallel sequencing analysis can provide important evidence to clarify the diagnosis. However, given the inter-tumor mutational heterogeneity in breast cancer, sufficiently large gene panels need to be employed to define clonality convincingly in all cases.
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